Instituto Politécnico Nacional, CICATA-IPN Querétaro, Cerro Blanco No. 141, Col. Colinas del Cimatario, C.P. 76090 Santiago de Querétaro, Querétaro, Mexico.
Instituto Politécnico Nacional, CICATA-IPN Querétaro, Cerro Blanco No. 141, Col. Colinas del Cimatario, C.P. 76090 Santiago de Querétaro, Querétaro, Mexico.
Adv Colloid Interface Sci. 2021 Sep;295:102398. doi: 10.1016/j.cis.2021.102398. Epub 2021 Mar 3.
Studying the interactions of biopolymers like polysaccharides and proteins is quite important mainly due to the wide number of applications such as the stabilization and encapsulation of active compounds in complex systems. Complexation takes place when materials like proteins and polysaccharides are blended to promote the entrapment of active compounds. The interaction forces between the charged groups in the polymeric chains allow the miscibility of the components in the complex system. Understanding the interactions taking place between the polymers as well as between the wall material and the active compound is important when designing delivery systems. However, some features of the biopolymers like structure, functional groups, or electrical charge as well as extrinsic parameters like pH or ratios might affect the structure and the performance of the complex system when used in encapsulation applications. This work summarizes the recent progress of the polysaccharide/protein complexes for encapsulation and the influence of the pH on the structural modifications during the complexation process.
研究生物聚合物（如多糖和蛋白质）的相互作用非常重要，主要是因为其在复杂系统中稳定和封装活性化合物等广泛应用。当像蛋白质和多糖这样的材料混合以促进活性化合物的包埋时，就会发生络合。聚合物链中带电基团之间的相互作用力允许复杂系统中各成分的混溶性。在设计递送系统时，了解聚合物之间以及壁材料和活性化合物之间发生的相互作用非常重要。然而，当用于封装应用时，生物聚合物的一些特性（如结构、官能团或电荷）以及外在参数（如 pH 值或比例）可能会影响复杂系统的结构和性能。本文总结了多糖/蛋白质复合物在封装中的最新进展以及 pH 值对络合过程中结构修饰的影响。
