Department of Paediatric Orthopaedics, Christian Medical College, Vellore, Tamil Nadu, India.
Center for Stem Cell Research, a unit of inStem Bengaluru, Christian Medical College, Vellore, Tamil Nadu, India.
Clin Transl Med. 2021 Apr;11(4):e385. doi: 10.1002/ctm2.385.
The safety of mesenchymal stem cell therapy for osteogenesis imperfecta has been demonstrated previously. However, it is unknown how the trophic effects are mediated by stem cells. In the present commentary, we bring to the attention of readers the recent report by Infante et al in the journal of clinical and translational medicine. The TERCELOI clinical trial presented the possible paracrine effect of transplanted MSCs in vitro and in vivo using proteomics and transcriptomic analysis. This novel finding adds new knowledge in the field of regenerative medicine. However, the scarcity of solid evidence in growth warrants a more thorough discussion.
先前已经证明间充质干细胞治疗成骨不全症具有安全性。然而，干细胞通过何种方式发挥营养作用尚不清楚。在本期评论中，我们提请读者注意 Infante 等人在《临床与转化医学杂志》上发表的最新报告。TERCELOI 临床试验使用蛋白质组学和转录组学分析，提出了移植的间充质干细胞在体外和体内的旁分泌作用的可能性。这一新颖的发现为再生医学领域增添了新知识。然而，在生长方面缺乏确凿证据，需要进行更深入的讨论。
