Stojanov Aleksandar, Bozovic Ivo, Stojanov Jelena, Palibrk Aleksa, Djordjevic Gordana, Basta Ivana, Malobabic Marina, Arsic Ana Azanjac, Peric Stojan
Neurology Clinic, University Clinical Centre Nis, Serbia.
Neurology Clinic, University Clinical Centre of Serbia, Belgrade, Serbia.
Clin Neurol Neurosurg. 2021 Apr 20;205:106654. doi: 10.1016/j.clineuro.2021.106654.
At a time of global health crisis, fear, anxiety, and stress levels increase. The effects of protracted social isolation, and media related misinformation's about the coronavirus disease 2019 (COVID-19) resulting in increased fear/stress related to the insufficiently known illness. The aim was to assess the influence of the COVID-19 health crisis on patients with chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).
A cross-sectional study on 29 adult CIDP patients was performed. The Medical Research Council scale was used to evaluate muscle strength. The degree of functional disability was measured using the Inflammatory Neuropathy Cause and Treatment disability scale. The overall quality of life (QoL) was self-estimated on a 0-100 numeric rating scale. We also used a specifically designed 22-question-survey about COVID-19.
Regarding the COVID-19 pandemic, 62% of CIDP patients were concerned. The daily activities of 55% of patients were negatively influenced by the pandemic. During the COVID-19 outbreak, 21% of patients reported their CIDP got worse. In 39% of CIDP patients, the influence of the pandemic on CIDP therapy was reported (reducing the dose or time interval or even discontinuation). The mean value of the self-estimated QoL was 64 ± 19. Independent predictors of worse QoL were age of patients (beta = -0.35, p < 0.05) and fear of the COVID-19 (beta = -0.34, p < 0.05).
The COVID-19 pandemic has a significant impact on CIDP patients. Besides the direct influence of the virus and fear of the virus, restrictive measures can indirectly harm the patients with CIDP.
在全球健康危机时期，恐惧、焦虑和压力水平会上升。长期社会隔离以及媒体传播的有关2019冠状病毒病（COVID-19）的错误信息，导致人们对这种了解不足的疾病产生更多恐惧/压力。本研究旨在评估COVID-19健康危机对慢性炎性脱髓鞘性多发性神经根神经病（CIDP）患者的影响。
对29例成年CIDP患者进行了横断面研究。采用医学研究委员会量表评估肌肉力量。使用炎性神经病病因与治疗残疾量表测量功能残疾程度。总体生活质量（QoL）通过0至100的数字评分量表进行自我评估。我们还使用了专门设计的关于COVID-19的22个问题的调查问卷。
关于COVID-19大流行，62%的CIDP患者表示担忧。55%的患者日常活动受到大流行的负面影响。在COVID-19疫情期间，21%的患者报告其CIDP病情恶化。39%的CIDP患者报告了大流行对CIDP治疗的影响（减少剂量或时间间隔甚至停药）。自我评估的QoL平均值为64±19。生活质量较差的独立预测因素是患者年龄（β=-0.35，p<0.05）和对COVID-19的恐惧（β=-0.34，p<0.05）。
COVID-19大流行对CIDP患者有重大影响。除了病毒的直接影响和对病毒的恐惧外，限制措施可能会间接伤害CIDP患者。
