Musche Venja, Bäuerle Alexander, Jahre Lisa, Schweda Adam, Dinse Hannah, Moradian Sheila, Weismüller Benjamin, Fink Madeleine, Wolters Anna, Fleischer Michael, Kleinschnitz Christoph, Teufel Martin, Skoda Eva-Maria, Stettner Mark
Clinic for Psychosomatic Medicine and Psychotherapy, University of Duisburg-Essen, LVR University Hospital, Essen, Germany.
Center for Translational Neuro- and Behavioral Sciences (C-TNBS), University of Duisburg-Essen, Essen, Germany.
Neurol Ther. 2022 Sep;11(3):1135-1146. doi: 10.1007/s40120-022-00359-3. Epub 2022 May 12.
This study investigated the mental health burden of patients with chronic inflammatory demyelinating polyneuropathy (CIDP) or multifocal motor neuropathy (MMN) during the COVID-19 pandemic in comparison to matched healthy controls.
The cross-sectional study included 59 patients with a diagnosis of either CIDP or MMN and 59 propensity score matched healthy controls. All participants completed a survey including demographics, distress (distress thermometer), depressive symptoms (PHQ-2), generalized anxiety (GAD-7), COVID-19-related fear, and risk perception. Additionally, patients with CIDP or MMN were asked about the frequency and type of infections since treatment initiation.
Patients with either CIDP or MMN reported experiencing reduced frequency or no differences in infection frequency since immune medication was initiated. Regarding COVID-19, patients with CIDP or MMN rated their risk of infection similar to healthy controls, while they expected a higher probability of the occurrence of symptoms, severe course, and dying of COVID-19. They reported increased depressive symptoms, generalized anxiety, and COVID-19-related fear in comparison to healthy controls.
Despite their personal experience of reduced frequency of infection since immune medication was initiated, patients with CIDP or MMN reported increased risk perception and prevalence of depressive symptoms, generalized anxiety, and COVID-19-related fear in comparison to healthy controls. This highlights the need for evidence-driven strategies to protect the mental health of this vulnerable group.
本研究调查了慢性炎性脱髓鞘性多发性神经病（CIDP）或多灶性运动神经病（MMN）患者在新冠疫情期间相较于匹配的健康对照者的心理健康负担。
这项横断面研究纳入了59例诊断为CIDP或MMN的患者以及59例倾向评分匹配的健康对照者。所有参与者均完成了一项调查，内容包括人口统计学信息、痛苦程度（痛苦温度计）、抑郁症状（PHQ-2）、广泛性焦虑（GAD-7）、与新冠相关的恐惧以及风险认知。此外，还询问了CIDP或MMN患者自开始治疗以来的感染频率和类型。
自开始使用免疫药物以来，CIDP或MMN患者报告感染频率降低或无差异。关于新冠，CIDP或MMN患者对自身感染风险的评估与健康对照者相似，而他们预计感染新冠后出现症状、病情严重及死亡的可能性更高。与健康对照者相比，他们报告的抑郁症状、广泛性焦虑及与新冠相关的恐惧有所增加。
尽管自开始使用免疫药物以来，CIDP或MMN患者个人经历的感染频率有所降低，但与健康对照者相比，他们报告的风险认知增加，抑郁症状、广泛性焦虑及与新冠相关的恐惧患病率更高。这凸显了采取循证策略保护这一弱势群体心理健康的必要性。
