Department of Health and Welfare, College of City Management, University of Taipei, Taipei, Taiwan.
Institute of Environmental and Occupational Health Sciences, College of Public Health, National Taiwan University, Taipei, Taiwan.
J Formos Med Assoc. 2021 Oct;120(10):1845-1854. doi: 10.1016/j.jfma.2021.04.009. Epub 2021 Apr 29.
BACKGROUND/PURPOSE: Heavy metals impair renal function, causing chronic kidney disease (CKD), and the petrochemical industry is one of the major environmental metal emission sources. This study aimed to investigate the relationship between renal function and metal exposure among the Taiwanese residents living near a petrochemical industry site.
We recruited residents near the No. 6 Naphtha Cracking Complex, and they were categorized into a high-exposure (HE) group (N = 190) in Taisi Village and a low-exposure (LE) group (N = 1184) in other villages of Dacheng Township in Changhua County of Taiwan. The urinary nickel, chromium, and vanadium levels of the study subjects were measured and the levels were standardized by urine creatinine, and the estimated glomerular filtration rates (eGFRs) were calculated to estimate renal function by one-time health data. Linear regression models were applied to illustrate the correlations between the distance to the complex and urinary metal levels and renal function; linear and logistic regression models were applied to evaluate the associations between urinary metal levels and renal function indicators.
The study subjects living closer to the petrochemical complex had significantly higher urinary nickel, chromium, and vanadium levels and worse renal function than study subjects living farther away. The urinary nickel and chromium levels of the study subjects were associated with their renal function indicators. When the subject's urinary nickel level increased 1-fold, the eGFR level significantly decreased by 0.820 ml/min/1.73 m.
Residents living closer to the petrochemical industry were exposed to higher metal levels and had worse renal function, and the nickel exposure of residents was potentially related to their decline in renal function.
背景/目的：重金属会损害肾功能，导致慢性肾脏病（CKD），而石化工业是主要的环境金属排放源之一。本研究旨在探讨居住在石化工业区附近的台湾居民肾功能与金属暴露之间的关系。
我们招募了位于第 6 号石脑油裂解厂附近的居民，并将他们分为高暴露（HE）组（N=190）和低暴露（LE）组（N=1184），分别来自彰化县大城乡的大西村和其他村庄。测量研究对象的尿镍、铬和钒水平，并通过尿肌酐标准化水平，通过一次性健康数据计算估计肾小球滤过率（eGFR）来评估肾功能。线性回归模型用于说明距离工厂与尿金属水平和肾功能之间的相关性；线性和逻辑回归模型用于评估尿金属水平与肾功能指标之间的关联。
居住在石化厂附近的研究对象尿镍、铬和钒水平显著较高，肾功能较差，与居住在较远的研究对象相比。研究对象的尿镍和铬水平与肾功能指标有关。当研究对象的尿镍水平增加 1 倍时，eGFR 水平显著下降 0.820 ml/min/1.73 m。
居住在石化工业区附近的居民暴露于较高的金属水平，肾功能较差，居民的镍暴露可能与其肾功能下降有关。
