He Eye Specialist Hospital, No.128 North Huanghe Street, Shenyang, China; The Second Affiliated Hospital of Dalian Medical University, Dalian, China.
He Eye Specialist Hospital, No.128 North Huanghe Street, Shenyang, China.
Cont Lens Anterior Eye. 2022 Apr;45(2):101449. doi: 10.1016/j.clae.2021.101449. Epub 2021 Apr 28.
The prevalence of contact lens related dry eye (CLDE) is high and can lead to ocular discomfort, reduced quality of vision and life. The aim of this study was to assess the efficacy of intense pulsed light (IPL) treatment in alleviating signs and symptoms of CLDE.
Prospective, randomised, examiner masked study.
This prospective study was conducted on 152 eyes of 76 patients (IPL group, n = 76 eyes; control group, n = 76 eyes) wearing contact lens (CL) and experiencing CLDE for more than 1 year. The IPL treatment group underwent two IPL treatment sessions at 3-week intervals while the control group received sham IPL treatment. Best-corrected visual acuity (BCVA), ocular surface disease index (OSDI), non-invasive breakup time (NITBUT), tear film lipid layer (TFLL) quality, fluorescein staining (FS), meibum gland (MG) quality and expression, endothelial cell count (ECC) and intraocular pressure (IOP) were assessed at baseline (D-0), day-21 (D-21) and day-42 (D-42) after IPL treatment.
The mean age of treatment group and control group was 28.47 ± 5.16 years (21 females, 28 %) and 28.58 ± 4.33 years (23 females, 30 %) respectively. IPL treatment group had clinically and statistically significant improvement in mean NITBUT was observed at D14 (5.24 s, P<0.001) and D28 (6.08 s, P<0.001). OSDI, TFLL score and MG quality and expressibility all improved significantly (P<0.001) at D-42, whereas BCVA, ECC and IOP showed no significant changes at D-21 and D-42 in IPL treatment group. The control group showed no significant improvement in all parameters at D-21 and D-42.
Our findings suggest that CL related DE can be safely alleviated with IPL treatment as it reduced the severity of symptoms, improved the overall tear film stability and reduced artificial tear use in participants with CLDE.
隐形眼镜相关干眼症（CLDE）的患病率很高，可导致眼部不适、视力和生活质量下降。本研究旨在评估强脉冲光（IPL）治疗缓解 CLDE 体征和症状的疗效。
前瞻性、随机、检查者盲法研究。
这项前瞻性研究共纳入 76 例（IPL 组 76 只眼，对照组 76 只眼）患者的 152 只眼，这些患者均患有 CLDE 超过 1 年且佩戴隐形眼镜。IPL 治疗组每 3 周进行 2 次 IPL 治疗，而对照组接受假 IPL 治疗。在基线（D-0）、第 21 天（D-21）和第 42 天（D-42）时评估最佳矫正视力（BCVA）、眼表疾病指数（OSDI）、非侵入性泪膜破裂时间（NITBUT）、泪膜脂质层（TFLL）质量、荧光素染色（FS）、睑板腺（MG）质量和表达、内皮细胞计数（ECC）和眼压（IOP）。
治疗组和对照组的平均年龄分别为 28.47 ± 5.16 岁（21 名女性，28%）和 28.58 ± 4.33 岁（23 名女性，30%）。治疗组在第 14 天（5.24 秒，P<0.001）和第 28 天（6.08 秒，P<0.001）时 NITBUT 的平均值有临床和统计学意义上的显著改善。在第 42 天，OSDI、TFLL 评分和 MG 质量和表达均有显著改善（P<0.001），而 BCVA、ECC 和 IOP 在 IPL 治疗组中在第 21 天和第 42 天没有明显变化。对照组在第 21 天和第 42 天所有参数均无明显改善。
我们的研究结果表明，CL 相关 DE 可以通过 IPL 治疗安全缓解，因为它减轻了症状的严重程度，改善了整体泪膜稳定性，并减少了 CLDE 患者对人工泪液的使用。
