睑板腺功能障碍所致干眼疾病不同模式强脉冲光治疗的网状Meta分析
Network meta-analysis of different modalities of intense pulsed light therapy in the treatment of dry eye disease induced by meibomian gland dysfunction.
作者信息
Cong Jing, Wu Yiting, Dong Chunqiong, Cheng Yiwen, Lin Xueqi, Yuan Jiayue, Feng Qianhong, Liu Shichu, Dai Jinhui, Ma Xiaoping, Xie Xinyi
机构信息
Department of Ophthalmology, Zhongshan Hospital, Fudan University, Shanghai, China.
Department of Radiology, Zhongshan Hospital, Fudan University, Shanghai, China.
出版信息
Lasers Med Sci. 2025 Jun 26;40(1):303. doi: 10.1007/s10103-025-04545-1.
PURPOSE
This network meta-analysis aimed to evaluate the comparative effect of five different protocols of IPL treatment in treating MGD-related DED, including optimal pulse technology [OPT]-based IPL, E > eye-based IPL, OPT-based IPL plus meibomian gland expression (MGX), E > eye-based IPL plus MGX, Eyesis-based IPL plus MGX.
METHODS
PubMed, Embase, Cochrane Library, SCOPUS and China National Knowledge Infrastructure (CNKI) were searched for eligible studies published before November 10, 2022.
RESULTS
Random network meta-analysis was conducted to estimate the differences between different protocols of IPL treatment in ocular surface disease index (OSDI), standard patient evaluation of eye dryness (SPEED), tear break-up time (TBUT), meibomian gland quality (MGQ), meibomian gland evaluation (MGE), and corneal fluorescein staining (CFS). Rank probability showed OPT-based IPL plus MGX ranked first in OSDI and SPEED, E > eye-based IPL plus MGX ranked first in TUBT, MGQ, and CFS, but Eyesis-based IPL plus MGX ranked first in MGE.
CONCLUSIONS
Based on available evidence, for individuals with MGD-related DED, OPT-based IPL plus MGX may be the preferred treatment protocol for relieving ocular symptoms, but E > eye-based IPL plus MGX may be more beneficial for improving ocular function.
目的
本网络荟萃分析旨在评估五种不同的强脉冲光（IPL）治疗方案在治疗睑板腺功能障碍相关干眼（MGD-related DED）中的比较效果，包括基于优化脉冲技术（OPT）的IPL、基于E＞eye的IPL、基于OPT的IPL联合睑板腺按摩（MGX）、基于E＞eye的IPL联合MGX、基于Eysis的IPL联合MGX。
方法
检索了PubMed、Embase、Cochrane图书馆、SCOPUS和中国知网（CNKI），以查找2022年11月10日前发表的符合条件的研究。
结果
进行随机网络荟萃分析，以估计不同IPL治疗方案在眼表疾病指数（OSDI）、干眼标准患者评估（SPEED）、泪膜破裂时间（TBUT）、睑板腺质量（MGQ）、睑板腺评估（MGE）和角膜荧光素染色（CFS）方面的差异。排序概率显示，基于OPT的IPL联合MGX在OSDI和SPEED方面排名第一，基于E＞eye的IPL联合MGX在TBUT、MGQ和CFS方面排名第一，但基于Eysis的IPL联合MGX在MGE方面排名第一。
结论
根据现有证据，对于MGD相关干眼患者，基于OPT的IPL联合MGX可能是缓解眼部症状的首选治疗方案，但基于E＞eye的IPL联合MGX可能对改善眼部功能更有益。
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