Boner A L, Vallone G, Brighenti C, Schiassi M, Miglioranzi P, Richelli C
Department of Pediatrics, University of Verona, Italy.
Pediatr Pulmonol. 1988;4(4):197-200. doi: 10.1002/ppul.1950040402.
Clenbuterol (C), a long-acting beta 2-selective bronchodilator was compared with salbutamol (S) in exercise-induced asthma (EIA) at two premedication time levels. Sixteen asthmatic children with EIA living at an altitude of 1,750 m were treated with C (0.001 mg/kg) and S (0.12 mg/kg), administered randomly in a double-blind cross-over study 90 and 300 minutes before exercise tests of running on a treadmill for 6 minutes. Pulmonary functions were evaluated prior to the administration of the drugs and immediately before, at the end of, and 2, 5, 10, 15, 20, and 25 minutes after exercise tests. In the preliminary screening exercise test the mean fall of FEV1 was 41.1%, but it was 21.0% and 27.1% after S and 21.9% and 19.9% after C administered 90 and 300 min prior to the test, respectively. Salbutamol administered 300 minutes before the test was statistically less effective than the same drug administered 90 minutes before the test or C administered 300 minutes before the test. Therefore, we can conclude that clenbuterol provides a more lasting protection than salbutamol in EIA.
在两个用药前时间水平下，将长效β2选择性支气管扩张剂克仑特罗（C）与沙丁胺醇（S）用于运动诱发性哮喘（EIA）的治疗进行比较。对16名居住在海拔1750米处患有EIA的哮喘儿童，采用克仑特罗（0.001毫克/千克）和沙丁胺醇（0.12毫克/千克）治疗，在跑步机上进行6分钟跑步运动测试前90分钟和300分钟，以双盲交叉研究方式随机给药。在给药前以及运动测试前、结束时以及结束后2、5、10、15、20和25分钟评估肺功能。在初步筛选运动测试中，第一秒用力呼气量（FEV1）平均下降41.1%，但在测试前90分钟和300分钟分别给予沙丁胺醇后，FEV1下降率为21.0%和27.1%，给予克仑特罗后为21.9%和19.9%。在测试前300分钟给予沙丁胺醇，在统计学上比在测试前90分钟给予相同药物或在测试前300分钟给予克仑特罗效果差。因此，我们可以得出结论，在运动诱发性哮喘中，克仑特罗比沙丁胺醇提供更持久的保护作用。
