克仑特罗治疗支气管哮喘的试验。
A trial of clenbuterol in bronchial asthma.
作者信息
Anderson G, Wilkins E
出版信息
Thorax. 1977 Dec;32(6):717-9. doi: 10.1136/thx.32.6.717.
Abstract
Clenbuterol is a beta 2-sympathomimetic bronchodilator. In a double-blind cross-over trial in 19 asthmatic patients with reversible airways obstruction, oral administration of both clenbuterol (40 microgram) and salbutamol (4 mg) caused significantly greater increased in peak expiratory flow rate (PEFR) than placebo, that of clenbuterol lasting longer. The patients' subjective assessment also suggested the relief of their symptoms by the active drugs. Side-effects were minimal.
摘要
克仑特罗是一种β2-拟交感神经支气管扩张剂。在一项针对19名患有可逆性气道阻塞的哮喘患者的双盲交叉试验中，口服克仑特罗（40微克）和沙丁胺醇（4毫克）均比安慰剂显著提高了呼气峰值流速（PEFR），且克仑特罗的作用持续时间更长。患者的主观评估也表明活性药物缓解了他们的症状。副作用极小。
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本文引用的文献
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An economical method of comparing inhaled bronchodilators in reversible diffuse airways obstruction. With special reference to a beta-2 stimulant--salmefamol.一种用于比较可逆性弥漫性气道阻塞中吸入性支气管扩张剂的经济方法。特别提及一种β-2兴奋剂——沙美特罗。
Thorax. 1974 May;29(3):317-22. doi: 10.1136/thx.29.3.317.
2
[Single and multiple applications and metabolite pattern of clenbuterol in man (author's transl)].
Arzneimittelforschung. 1976;26(7a):1446-50.
3
The bronchodilator effect of NAB 365.NAB 365的支气管扩张作用。
Br J Clin Pharmacol. 1977 Feb;4(1):67-71. doi: 10.1111/j.1365-2125.1977.tb00669.x.
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