Dermatology Clinic, University of Catania, Catania, Italy.
J Cosmet Dermatol. 2021 Apr;20 Suppl 1(Suppl 1):23-27. doi: 10.1111/jocd.14097.
Intertrigo is a recurrent inflammatory dermatosis involving large/small body folds. Skin barrier products represent the mainstay of treatment in uncomplicated mild/moderate intertrigo.
To assess by clinical and instrumental evaluation the efficacy and tolerability of a new barrier spray containing zinc gluconate-taurine complex and zinc oxide combined with panthenol, glycerin, and Shea (Butyrospermum parkii) butter in mild-to-moderate intertrigo in athletes and overweight subjects.
In this open-label prospective trial, 20 adult patients, with mild/moderate intertrigo enrolled at the Dermatology University Clinic of Catania (Italy), were instructed to apply the spray twice daily for 30 days. Degree of erythema was performed clinically and by polarized dermoscopy using a 5-point severity scale (from 0=no erythema to 4=severe erythema) at baseline, and at 15 and 30 days. The measurement of pruritus was carried out by a subject-completed visual analog scale (VAS) (from 0 mm=no pruritus to 100 mm=severe pruritus), at all time points. An Investigator Global Assessment (IGA) using a 6-point scale (from -1=worsening to 4=complete response/clear) was also conducted at 30 days, along with a self-administered tolerability questionnaire. Statistical analysis was performed using SAS version 9.
At 15 days, a statically significant reduction from baseline in erythema severity (mean from 3.4 ± 0.3 to 2.5 ± 0.2) along with pruritus intensity (mean from 70 ± 15.4 mm to 40 ± 9.5 mm) was observed. At 30 days, all evaluated parameters showed a further progressive statistically significant reduction from baseline. No relevant side effects were recorded.
Our results suggest that the tested spay containing antiseptic/anti-inflammatory and anti-irritation agents may represent a valid therapeutic option for mild/moderate intertrigo.
间擦疹是一种反复发作的炎症性皮肤病，涉及大/小身体褶皱。皮肤屏障产品是治疗简单轻度/中度间擦疹的主要方法。
通过临床和仪器评估，评估一种新的含有葡萄糖酸锌-牛磺酸复合物和氧化锌的屏障喷雾在运动员和超重人群中治疗轻度至中度间擦疹的疗效和耐受性，同时该喷雾还含有泛醇、甘油和乳木果（牛油果树）脂。
在这项开放标签前瞻性试验中，意大利卡塔尼亚大学皮肤科诊所招募了 20 名患有轻度/中度间擦疹的成年患者，他们被指示每天使用喷雾两次，持续 30 天。在基线、第 15 天和第 30 天，使用 5 分制严重程度量表（0=无红斑至 4=严重红斑）进行临床和偏振光皮肤镜评估红斑程度；在所有时间点，通过患者完成的视觉模拟量表（VAS）（0 毫米=无瘙痒至 100 毫米=严重瘙痒）测量瘙痒程度。还在第 30 天进行了研究者总体评估（IGA），使用 6 分制（-1=恶化至 4=完全缓解/清除），同时进行了自我管理的耐受性问卷。使用 SAS 版本 9 进行统计分析。
在第 15 天，与基线相比，红斑严重程度（从 3.4±0.3 降至 2.5±0.2）和瘙痒强度（从 70±15.4 毫米降至 40±9.5 毫米）均有统计学显著降低。在第 30 天，所有评估参数均从基线进一步显著降低。未记录到任何相关的不良反应。
我们的结果表明，含有防腐/抗炎和抗刺激剂的测试喷雾可能是治疗轻度/中度间擦疹的有效治疗选择。
