Micali Giuseppe, Pulvirenti Nella, Dall'Oglio Federica, Tedeschi Aurora, Quattrocchi Enrica, Lacarrubba Francesco
Dermatology Clinic, University of Catania, Catania, Italy.
Dermatology Department, Mayo Clinic Rochester, MN, USA.
J Cosmet Dermatol. 2021 Apr;20 Suppl 1(Suppl 1):14-17. doi: 10.1111/jocd.14095.
Cradle cap is a benign and self-limiting variant of seborrheic dermatitis (SD) that can be distressing for parents.
To assess by clinical/laboratory/instrumental evaluation the efficacy/tolerability of a gel cream containing piroctone olamine (antifungal), biosaccharide gum-2 (antifungal), stearyl glycyrrhetinate (anti-inflammatory), and zinc l-pyrrolidone carboxylate (zinc-PCA) (antiseborrheic) in the treatment of mild/ moderate cradle cap.
In this prospective, open-label trial, 10 infants, with mild/moderate cradle cap enrolled at the Dermatology University Clinic of Catania (Italy) used the tested gel cream twice daily for 30 days. Degree of erythema was evaluated clinically by a 5-point severity scale (from 0=no erythema to 4=severe erythema), at baseline, at 15 and 30 days. Desquamation was rated by dermoscopy evaluation using a 5-point scale (from 0=no desquamation to 4=severe/many large adherent white flakes), at all time points. An Investigator Global Assessment (IGA) using a 6-point scale (from -1=worsening to 4=complete response/clear) was also performed at 30 days. Five subjects, randomly selected, underwent double microbiological evaluation for bacteria and yeasts by cultures of cotton swabs at baseline and at 30 days. Tolerability/acceptability was evaluated on a 4-point scale (from 0=very poor to 3=excellent) at 15 and 30 days. Data were processed using SAS version 9.
At baseline, a significant colony-forming unit (CFU) count for Malassezia furfur and Staphylococcus aureus was detected in 4 out of 5 selected patients. After 15 and 30 days, a statically significant reduction from baseline in erythema and desquamation severity was observed, along with a reduction in CFU count for Malassezia furfur and Staphylococcus aureus from baseline. No signs of local side effects were documented.
Our results indicate that the tested gel cream may represent a valid option to treat mild-to-moderate forms of cradle cap and support its antifungal and antibacterial properties.
摇篮帽是脂溢性皮炎（SD）的一种良性且自限性的变体，会让家长感到困扰。
通过临床/实验室/仪器评估，来评定一种含有氯咪巴唑（抗真菌）、生物糖胶-2（抗真菌）、硬脂醇甘草亭酸酯（抗炎）和L-吡咯烷酮羧酸钠锌（锌-PCA）（抗脂溢）的凝胶霜治疗轻度/中度摇篮帽的疗效/耐受性。
在这项前瞻性、开放标签试验中，10名患有轻度/中度摇篮帽的婴儿在意大利卡塔尼亚大学皮肤科诊所入组，每天使用受试凝胶霜两次，持续30天。在基线、第15天和第30天，通过5分严重程度量表（从0=无红斑到4=严重红斑）临床评估红斑程度。在所有时间点，通过皮肤镜检查评估使用5分制量表（从0=无脱屑到4=严重/许多大的附着白色鳞屑）对脱屑进行评分。在第30天还进行了使用6分制量表（从-1=恶化到4=完全缓解/清除）的研究者整体评估（IGA）。随机选择5名受试者，在基线和第30天通过棉签培养对细菌和酵母菌进行双重微生物学评估。在第15天和第30天，以4分制量表（从0=非常差到3=优秀）评估耐受性/可接受性。使用SAS 9版处理数据。
在基线时，5名入选患者中有4名检测到糠秕马拉色菌和金黄色葡萄球菌的显著菌落形成单位（CFU）计数。在第15天和第30天后，观察到红斑和脱屑严重程度较基线有统计学意义的显著降低，同时糠秕马拉色菌和金黄色葡萄球菌的CFU计数较基线减少。未记录到局部副作用的迹象。
我们的结果表明，受试凝胶霜可能是治疗轻度至中度摇篮帽的有效选择，并支持其抗真菌和抗菌特性。
