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出院后在门诊随访可改善心力衰竭患者的长期再入院率和预后。

Early follow-up at outpatient care after discharge improves long-term heart failure readmission rate and prognosis.

机构信息

Division of Cardiology, Fukuoka Red Cross Hospital, 3-1-1, Okusu, Minami-ku, Fukuoka, 815-8555, Japan.

出版信息

ESC Heart Fail. 2021 Aug;8(4):3002-3013. doi: 10.1002/ehf2.13391. Epub 2021 May 2.

Abstract

AIMS

It has been reported that congestive heart failure (CHF) readmission has not decreased in the last decade. It is also reported that CHF readmission is likely to occur shortly after discharge. We investigated whether an early follow-up at outpatient care within 2 weeks after discharge affects the long-term readmission rate and prognosis.

METHODS AND RESULTS

We reviewed consecutive 1002 patients admitted to our hospital due to CHF. Two-hundred and fifty-nine patients who died in-hospital or were transferred to another hospital or readmitted within 2 weeks were excluded and 743 of discharged patients were analysed. We extracted contributing variables associated with heart failure (HF) readmission and the composite adverse outcome (all cause death or HF readmissions) by univariate and multivariate analysis. Multivariate analysis showed that the early follow-up was independently associated with freedom from HF readmission and the composite outcome. We divided these patients into two groups, with/without early follow-up and performed a propensity score-matching analysis (n = 259 each). HF readmission during 2 year follow-up was significantly less in the early follow-up group [P = 0.02, hazard ratio (HR) = 0.647, 95% confidence interval (CI) = 0.447-0.935] as well as the composite outcome was less in the early follow-up group (P = 0.01, HR = 0.643, 95% CI = 0.456-0.908). Medication adjustments were done in only 33.2% of the patients. Rates of HF readmissions were comparable regardless of whether or not medication adjustment was done at the early follow-up (P = 0.505, HR = 1.208, 95% CI = 0.692-2.106).

CONCLUSIONS

The present study demonstrates that an early follow-up approach after discharge in CHF patients may improve the long-term prognosis. These results may not depend on medication adjustment but rather on modifying patient factors early after discharge.

摘要

目的

据报道,充血性心力衰竭(CHF)的再入院率在过去十年中并未降低。据报道,CHF 再入院很可能在出院后不久发生。我们研究了出院后 2 周内进行早期门诊随访是否会影响长期再入院率和预后。

方法和结果

我们回顾了因 CHF 住院的连续 1002 例患者。排除了住院期间死亡或转院或在 2 周内再入院的 259 例患者,分析了 743 例出院患者。我们通过单因素和多因素分析提取与心力衰竭(HF)再入院和复合不良结局(全因死亡或 HF 再入院)相关的变量。多因素分析显示,早期随访与 HF 再入院和复合结局的无事件生存独立相关。我们将这些患者分为有/无早期随访两组,并进行倾向评分匹配分析(每组 n=259)。在 2 年随访期间,早期随访组 HF 再入院显著减少[P=0.02,风险比(HR)=0.647,95%置信区间(CI)=0.447-0.935],复合结局也显著减少(P=0.01,HR=0.643,95%CI=0.456-0.908)。仅对 33.2%的患者进行了药物调整。无论早期随访是否进行药物调整,HF 再入院率均无差异(P=0.505,HR=1.208,95%CI=0.692-2.106)。

结论

本研究表明,CHF 患者出院后进行早期随访可能会改善长期预后。这些结果可能不依赖于药物调整,而是通过在出院后早期改变患者因素来实现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2c52/8318498/4302a44fb8c7/EHF2-8-3002-g001.jpg

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