Department of Pathology, Gyeongsang National University Changwon Hospital, Changwon, South Korea.
Department of Pathology, Gyeongsang National University College of Medicine, Jinju, South Korea.
Thorac Cancer. 2021 Jun;12(11):1673-1680. doi: 10.1111/1759-7714.13985. Epub 2021 May 2.
Smoking- and nonsmoking-associated lung cancers have different mechanisms of carcinogenesis. We divided non-small cell lung cancer (NSCLC) patients into nonsmoking and smoking groups with the aim of trying to understand the utility of brain-specific angiogenesis inhibitor 1 (BAI1) expression in the separate groups.
Clinicopathological data were obtained from 148 patients who had undergone surgery for NSCLC of the lung. Tissue microarray blocks were made of samples from NSCLC patients. Two pathologists graded the intensity of BAI1 expression as high or low expression in the cancer cells of patients in the smoking and nonsmoking groups.
NSCLC nonsmokers with higher BAI1 nuclear expression had poor disease-specific survival (DSS) (hazard ratio: 2.679; 95% confidence interval [CI]:1.022-7.022, p = 0.045). The Kaplan-Meier survival curve confirmed that higher BAI1 expression was significantly associated with poor DSS (p = 0.034) in the nonsmoking group.
We divided NSCLC patients into nonsmoking and smoking groups and found that nuclear BAI1 expression was related to patient survival in nonsmoking NSCLC patients. We suggest BAI1 expression as a predictive marker of nonsmoking-associated NSCLC and recommend that it be evaluated as an AJCC staging criterion in the future.
吸烟相关和非吸烟相关的肺癌具有不同的致癌机制。我们将非小细胞肺癌（NSCLC）患者分为不吸烟组和吸烟组，旨在了解脑特异性血管生成抑制剂 1（BAI1）在两组中的表达的作用。
从 148 例接受肺癌 NSCLC 手术的患者中获得临床病理数据。制作 NSCLC 患者的组织微阵列块。两位病理学家对吸烟组和不吸烟组患者的癌细胞中 BAI1 表达的强度进行高或低表达分级。
核表达较高的非吸烟 NSCLC 患者疾病特异性生存率（DSS）较差（风险比：2.679；95%置信区间[CI]：1.022-7.022，p=0.045）。Kaplan-Meier 生存曲线证实，较高的 BAI1 表达与不吸烟组的较差 DSS 显著相关（p=0.034）。
我们将 NSCLC 患者分为不吸烟组和吸烟组，发现核 BAI1 表达与不吸烟 NSCLC 患者的生存有关。我们建议将 BAI1 表达作为非吸烟相关 NSCLC 的预测标志物，并建议将其作为未来 AJCC 分期标准进行评估。
