Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center, Torrance, CA, USA.
Lundquist Institute for Biomedical Innovation at Harbor UCLA Medical Center, Torrance, CA, USA.
Nutr Metab Cardiovasc Dis. 2021 Jun 7;31(6):1767-1773. doi: 10.1016/j.numecd.2021.02.027. Epub 2021 Mar 4.
Obesity and osteoporosis are two important and growing public health problems worldwide. Body mass index (BMI) has been found to be inversely related to the risk of osteoporotic fracture. We aimed to assess the association of BMI with thoracic vertebral bone mineral density (BMD) measured from a quantitative computed tomography (QCT).
We retrospectively evaluated the data from 15,758 consecutive patients (5675 females and 10,083 males) between age 20-90 years, who underwent Coronary Artery Calcium (CAC) scoring. Quantitative data analyses of thoracic trabecular BMD (mg/cm) was performed with a phantom system or phantomless using validated software. The gender-specific subgroup was divided based on age (<45, 45-55, 55-65, >65 yrs in females; <40,40-60,>60 yrs in Males) and weight by BMI (kg/m) as < 25 (normal or low weight), >25 - <30 (overweight) and >30 (obesity). Analysis of variance (ANOVA) and Scheffe's post hoc procedure tested the association of body weight/BMI on BMD. A significant positive association between the body weight and BMD existed in obese population in elder groups in both genders (p < 0.05). There was no significant difference in BMD in 40-60 years in men and <55 years in women with normal or low weight compared to overweight or obese cohorts.
We concluded that the effect of weight on BMD is age-specific and the BMD should be monitored routinely with a cardiac CT scan in the senile population.
肥胖症和骨质疏松症是全球两个重要且日益严重的公共卫生问题。体重指数（BMI）与骨质疏松性骨折风险呈负相关。我们旨在评估 BMI 与定量计算机断层扫描（QCT）测量的胸腰椎骨矿物质密度（BMD）之间的相关性。
我们回顾性评估了年龄在 20-90 岁之间的 15758 例连续患者（女性 5675 例，男性 10083 例）的冠状动脉钙评分（CAC）数据。使用经过验证的软件，通过体模系统或无体模对胸腰椎小梁 BMD（mg/cm）进行定量数据分析。根据年龄（女性<45、45-55、55-65、>65 岁；男性<40、40-60、>60 岁）和体重按 BMI（kg/m）分为亚组，<25（正常或低体重）、>25-<30（超重）和>30（肥胖）。采用方差分析（ANOVA）和 Scheffe 事后检验分析体重/ BMI 与 BMD 的相关性。在两性中，肥胖人群的高龄组体重与 BMD 之间存在显著正相关（p<0.05）。与超重或肥胖组相比，正常或低体重的男性 40-60 岁和女性<55 岁的 BMD 无显著差异。
我们得出结论，体重对 BMD 的影响具有年龄特异性，在老年人群中应常规通过心脏 CT 扫描监测 BMD。
