Department of Food and Nutrition, College of Natural Science and Public Health and Safety, Chosun University, Gwangju, Republic of Korea.
Department of Pharmacy, College of Pharmacy, Chosun University, 309 Pilmun-daero, Dong-gu, Gwangju, 61452, Republic of Korea.
J Health Popul Nutr. 2023 Sep 12;42(1):97. doi: 10.1186/s41043-023-00443-w.
This study aimed to examine the associations between osteoporosis and hand grip strength (HGS), a surrogate marker of muscular strength, among Korean adults stratified by body mass index (BMI), age, and renal function.
This study was conducted using the data obtained from the Korea National Health and Nutrition Examination Survey 2015-2019, a cross-sectional and nationally representative survey performed by the Korea Centers for Diseases Control and Prevention.
Of the 26,855 subjects included in this study, those with low muscle strength (LMS) and normal muscle strength were showed in 4,135 (15.4%) and 22,720 (84.6%) subjects, respectively. The osteoporotic subjects had a higher prevalence rate for LMS than those without osteoporosis after adjusting for age [odds ratio (OR), 1.684; 95% confidence interval (CI), 1.500-1.890). The subjects with osteoporosis and BMI < 18.5 kg/m also had a higher prevalence rate for LMS after adjusting for age compared to those with non-osteoporosis and BMI < 18.5 kg/m (OR, 1.872; 95% CI, 1.043-3.359). Compared to the non-osteoporotic subjects with estimated glomerular filtration rate (eGFR) ≥ 60 mL/min/1.73 m, those with osteoporosis and eGFR ≥ 60 mL/min/1.73 m had a higher prevalence rate for LMS after controlling for age and sex (OR, 1.630; 95% CI, 1.427-1.862).
The results showed that osteoporosis was likely to contribute to an increased prevalence rate of LMS in terms of HGS. Aging, BMI, and renal function also had significant effects on the association between osteoporosis and LMS. This association is likely to assist in developing better strategies to estimate bone health in clinical or public health practice.
本研究旨在探讨骨质疏松症与手握力（HGS）之间的关联，HGS 是肌肉力量的替代标志物，研究对象在韩国成年人中按体重指数（BMI）、年龄和肾功能进行分层。
本研究使用了韩国疾病控制与预防中心进行的 2015-2019 年全国健康和营养调查的数据。
在纳入的 26855 名受试者中，肌肉力量低（LMS）和正常肌肉力量的受试者分别为 4135（15.4%）和 22720（84.6%）。调整年龄后，骨质疏松症患者的 LMS 患病率高于非骨质疏松症患者[比值比（OR），1.684；95%置信区间（CI），1.500-1.890）。调整年龄后，与非骨质疏松症且 BMI<18.5kg/m2的患者相比，骨质疏松症且 BMI<18.5kg/m2的患者 LMS 的患病率更高（OR，1.872；95%CI，1.043-3.359）。与估计肾小球滤过率（eGFR）≥60mL/min/1.73m 的非骨质疏松症患者相比，eGFR≥60mL/min/1.73m 的骨质疏松症患者在控制年龄和性别后，LMS 的患病率更高（OR，1.630；95%CI，1.427-1.862）。
结果表明，骨质疏松症可能导致 HGS 中 LMS 的患病率增加。年龄、BMI 和肾功能对骨质疏松症与 LMS 之间的关联也有显著影响。这种关联可能有助于制定更好的策略，以在临床或公共卫生实践中评估骨骼健康。
