Institute of Physical Activity and Sport Sciences, Cruzeiro do Sul University, São Paulo, SP, Brazil.
Institute of Physical Activity and Sport Sciences, Cruzeiro do Sul University, São Paulo, SP, Brazil; School of Arts, Sciences and Humanities, University of São Paulo, São Paulo, SP, Brazil.
Neurophysiol Clin. 2021 Jun;51(3):279-285. doi: 10.1016/j.neucli.2021.03.005. Epub 2021 Apr 30.
Sensory information is crucial when performing daily activities, and Parkinson's disease may diminish sensitivity to sensory cues. This study aimed to examine the detection threshold of passive motion of knee and ankle joints in individuals with Parkinson's disease.
Eighteen individuals in the early stages of idiopathic Parkinson's disease (age: 62.7 ± 7.3 years) and 18 healthy matched controls (age: 62.5 ± 7.1 years) first performed a simple reaction time test. Participants were asked to perform ten trials, during which they had to watch a square on a screen and press a button as quickly as possible when the square lit up. Thereafter, the participants were tested for their detection threshold of passive motion of their lower limb joints. Participants were seated in a specially designed chair and their knee or ankle joint was passively moved at a velocity of 0.5º/s. Participants kept their eyes closed and were instructed to press a button as quickly as possible when any joint motion was detected.
Individuals with Parkinson's disease needed more time to perform the reaction time test than did the control participants. Individuals with Parkinson's disease also needed larger angular displacement, even when reaction time was used as a covariate measure, to detect any passive motion, in both knee (0.70º ± 0.20º) and ankle (1.03º ± 0.23º) joints than did the control participants [(0.57º ± 0.20º) and (0.84º ± 0.27º), respectively].
Impaired joint proprioception can be observed in the early stages of Parkinson's disease, which may compromise the use of proprioception cues from lower limbs.
在进行日常活动时，感觉信息至关重要，而帕金森病可能会降低对感觉提示的敏感性。本研究旨在检查帕金森病患者膝关节和踝关节被动运动的检测阈值。
18 名特发性帕金森病早期患者（年龄：62.7±7.3 岁）和 18 名健康匹配的对照者（年龄：62.5±7.1 岁）首先进行了简单反应时测试。参与者被要求进行十次试验，在此期间，他们必须观看屏幕上的一个正方形，当正方形亮起时，尽快按下按钮。之后，测试参与者下肢关节被动运动的检测阈值。参与者坐在特制的椅子上，他们的膝盖或脚踝关节以 0.5º/s 的速度被动移动。参与者闭上眼睛，当检测到任何关节运动时，被指示尽快按下按钮。
帕金森病患者完成反应时间测试所需的时间比对照组参与者长。即使将反应时间作为协变量测量，帕金森病患者也需要更大的角度位移才能检测到任何被动运动，无论是在膝关节（0.70º±0.20º）还是踝关节（1.03º±0.23º），都大于对照组参与者的（0.57º±0.20º）和（0.84º±0.27º）。
在帕金森病的早期阶段可以观察到关节本体感觉受损，这可能会影响对下肢本体感觉提示的使用。
