Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Korea.
KAIST Institute for the BioCentury, KAIST, Daejeon 34141, Korea.
Mol Cells. 2021 Apr 30;44(4):187-194. doi: 10.14348/molcells.2021.0045.
Inositol phosphates are water-soluble intracellular signaling molecules found in eukaryotes from yeasts to mammals, which are synthesized by a complex network of enzymes including inositol phosphate kinases. Among these, inositol polyphosphate multikinase (IPMK) is a promiscuous enzyme with broad substrate specificity, which phosphorylates multiple inositol phosphates, as well as phosphatidylinositol 4,5-bisphosphate. In addition to its catalytic actions, IPMK is known to non-catalytically control major signaling events via direct protein-protein interactions. In this review, we describe the general characteristics of IPMK, highlight its pleiotropic roles in various physiological and pathological conditions, and discuss future challenges in the field of IPMK signaling pathways.
肌醇磷酸盐是真核生物（从酵母到哺乳动物）中水溶性的细胞内信号分子，由包括肌醇磷酸盐激酶在内的复杂酶网络合成。其中，肌醇多磷酸盐激酶（IPMK）是一种具有广泛底物特异性的混杂酶，可磷酸化多种肌醇磷酸盐以及磷脂酰肌醇 4,5-二磷酸。除了其催化作用外，IPMK 还通过直接的蛋白质-蛋白质相互作用非催化性地控制主要信号事件。在这篇综述中，我们描述了 IPMK 的一般特征，强调了它在各种生理和病理条件下的多效性作用，并讨论了 IPMK 信号通路领域的未来挑战。
