West African Centre for Cell Biology of Infectious Pathogens, College of Basic and Applied Sciences, University of Ghana, P.O. Box LG 54, Legon, Accra, Ghana.
Department of Biomedical Engineering, School of Engineering Sciences, College of Basic and Applied Sciences, University of Ghana, P.O. Box LG77, Legon, Accra, Ghana.
ScientificWorldJournal. 2021 Apr 10;2021:6641128. doi: 10.1155/2021/6641128. eCollection 2021.
Till date, there is no known antidote to cure diabetes mellitus despite the discovery and development of diverse pharmacotherapeutic agents many years ago. Technological advancement in natural product chemistry has led to the isolation of analogs of vitexin and isovitexin found in diverse bioresources. These compounds have been extensively studied to explore their pharmacological relevance in diabetes mellitus. . The present review was to compile results from in vitro and in vivo studies performed with vitexin and isovitexin derivatives relating to diabetes mellitus and its complications. A systematic online literature query was executed to collect all relevant articles published up to March 2020.
In this piece, we have collected data and presented it in a one-stop document to support the multitargeted mechanistic actions of vitexin and isovitexin in controlling diabetes mellitus and its complications.
Data collected hint that vitexin and isovitexin work by targeting diverse pathophysiological and metabolic pathways and molecular drug points involved in the clinical manifestations of diabetes mellitus. This is expected to provide a deeper understanding of its actions and also serve as a catapult for clinical trials and application research.
尽管多年前发现并开发了多种药物治疗方法，但目前仍没有已知的治疗糖尿病的解毒剂。天然产物化学的技术进步导致了从各种生物资源中分离出牡荆素和异牡荆素的类似物。这些化合物已被广泛研究，以探索其在糖尿病中的药理学相关性。本综述旨在收集与糖尿病及其并发症相关的体外和体内研究中使用牡荆素和异牡荆素衍生物的结果。系统地在线文献检索收集了截至 2020 年 3 月发表的所有相关文章。
在这篇文章中，我们收集了数据并将其整理在一个文档中，以支持牡荆素和异牡荆素在控制糖尿病及其并发症方面的多种靶向作用机制。
收集的数据表明，牡荆素和异牡荆素通过针对糖尿病临床表现涉及的多种病理生理和代谢途径以及分子药物靶点发挥作用。这有望加深对其作用的理解，并为临床试验和应用研究提供跳板。
