Zhang Xi-Le, Zhang Xiao-Guang, Huang Yan-Ran, Zheng Yan-Yan, Ying Peng-Jie, Zhang Xiao-Jie, Lu Xiao, Wang Yi-Jing, Zheng Guo-Qing
Department of Neurology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Front Cell Neurosci. 2021 Apr 14;15:628908. doi: 10.3389/fncel.2021.628908. eCollection 2021.
Stem cell transplantation offers promise in the treatment of ischemic stroke. Here we utilized systematic review, meta-analysis, and meta-regression to study the biological effect of stem cell treatments in animal models of ischemic stroke. A total of 98 eligible publications were included by searching PubMed, EMBASE, and Web of Science from inception to August 1, 2020. There are about 141 comparisons, involving 5,200 animals, that examined the effect of stem cell transplantation on neurological function and infarct volume as primary outcome measures in animal models for stroke. Stem cell-based therapy can improve both neurological function (effect size, -3.37; 95% confidence interval, -3.83 to -2.90) and infarct volume (effect size, -11.37; 95% confidence interval, -12.89 to -9.85) compared with controls. These results suggest that stem cell therapy could improve neurological function deficits and infarct volume, exerting potential neuroprotective effect for experimental ischemic stroke, but further clinical studies are still needed.
干细胞移植为缺血性中风的治疗带来了希望。在此，我们运用系统评价、荟萃分析和荟萃回归来研究干细胞治疗在缺血性中风动物模型中的生物学效应。通过检索PubMed、EMBASE和Web of Science数据库，从建库至2020年8月1日，共纳入98篇符合条件的出版物。约有141项比较，涉及5200只动物，这些研究将干细胞移植对神经功能和梗死体积的影响作为中风动物模型的主要结局指标进行了检测。与对照组相比，基于干细胞的治疗可改善神经功能（效应量为 -3.37；95%置信区间为 -3.83至 -2.90）和梗死体积（效应量为 -11.37；95%置信区间为 -12.89至 -9.85）。这些结果表明，干细胞治疗可改善神经功能缺损和梗死体积，对实验性缺血性中风发挥潜在的神经保护作用，但仍需进一步的临床研究。
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