Liu Jianyang, He Jialin, Huang Yan, Hu Zhiping
Department of Neurology, The Second Xiangya Hospital, Central South University, Changsha, China.
National Health Commission Key Laboratory of Birth Defects Research, Prevention, and Treatment, Hunan Provincial Maternal and Child Health Care Hospital, Changsha, China.
Front Pharmacol. 2021 Dec 20;12:795409. doi: 10.3389/fphar.2021.795409. eCollection 2021.
Resveratrol, a natural polyphenolic phytoalexin, is broadly presented in dietary sources. Previous research has suggested its potential neuroprotective effects on ischemic stroke animal models. However, these results have been disputable. Here, we conducted a meta-analysis to comprehensively evaluate the effect of resveratrol treatment in ischemic stroke rodent models. To comprehensively evaluate the effect of resveratrol treatment in ischemic stroke rodent models. A literature search of the databases Pubmed, Embase, and Web of science identified 564 studies that were subjected to pre-defined inclusion criteria. 54 studies were included and analyzed using a random-effects model to calculate the standardized mean difference (SMD) with corresponding confidence interval (CI). As compared with controls, resveratrol significantly decreased infarct volume (SMD -4.34; 95% CI -4.98 to -3.69; < 0.001) and the neurobehavioral score (SMD -2.26; 95% CI -2.86 to -1.67; < 0.001) in rodents with ischemic stroke. Quality assessment was performed using a 10-item checklist. Studies quality scores ranged from 3 to 8, with a mean value of 5.94. In the stratified analysis, a significant decrease of infarct volume and the neurobehavioral score was achieved in resveratrol sub-groups with a dosage of 20-50 mg/kg. In the meta-regression analysis, the impact of the delivery route on an outcome is the possible source of high heterogeneity. Generally, resveratrol treatment presented neuroprotective effects in ischemic stroke models. Furthermore, this study can direct future preclinical and clinical trials, with important implications for human health.
白藜芦醇是一种天然的多酚类植物抗毒素，广泛存在于膳食来源中。先前的研究表明其对缺血性中风动物模型具有潜在的神经保护作用。然而，这些结果一直存在争议。在此，我们进行了一项荟萃分析，以全面评估白藜芦醇治疗对缺血性中风啮齿动物模型的影响。为了全面评估白藜芦醇治疗对缺血性中风啮齿动物模型的影响。对数据库PubMed、Embase和Web of science进行文献检索，确定了564项符合预先定义纳入标准的研究。纳入54项研究并使用随机效应模型进行分析，以计算标准化平均差（SMD）及相应的置信区间（CI）。与对照组相比，白藜芦醇显著降低了缺血性中风啮齿动物的梗死体积（SMD -4.34；95%CI -4.98至-3.69；<0.001）和神经行为评分（SMD -2.26；95%CI -2.86至-1.67；<0.001）。使用10项清单进行质量评估。研究质量得分范围为3至8，平均值为5.94。在分层分析中，剂量为20 - 50mg/kg的白藜芦醇亚组梗死体积和神经行为评分显著降低。在荟萃回归分析中，给药途径对结果的影响是高异质性的可能来源。总体而言，白藜芦醇治疗在缺血性中风模型中呈现出神经保护作用。此外，本研究可为未来的临床前和临床试验提供指导，对人类健康具有重要意义。
