Wang Xiwu, Lv Zhaoting, Wu Qian, Liu Huitao, Gu Yanrou, Ye Teng
Department of Psychiatry, Wenzhou Seventh People's Hospital, Wenzhou, China.
Department of Psychiatry, Tongde Hospital of Zhejiang Province, Hangzhou, China.
Front Aging Neurosci. 2021 Apr 15;13:592845. doi: 10.3389/fnagi.2021.592845. eCollection 2021.
There is growing evidence that testosterone may be implicated in the pathogenesis of Alzheimer's disease (AD). We aimed to examine the relationship between plasma total testosterone levels and change in brain glucose metabolism over time among non-demented older people.
The association of plasma total testosterone levels with change in brain glucose metabolism among non-demented older people was investigated cross-sectionally and longitudinally. Given a significant difference in levels of plasma total testosterone between gender, we performed our analysis in a sex-stratified way. At baseline, 228 non-demented older people were included: 152 males and 76 females.
In the cross-sectional analysis, no significant relationship between plasma total testosterone levels and brain glucose metabolism was found in males or females. In the longitudinal analysis, we found a significant association of plasma total testosterone levels with change in brain glucose metabolism over time in males, but not in females. More specifically, in males, higher levels of total testosterone in plasma at baseline were associated with slower decline in brain glucose metabolism.
We found that higher levels of total testosterone in plasma at baseline were associated with slower decline in brain glucose metabolism in males without dementia, indicating that testosterone may have beneficial effects on brain function.
越来越多的证据表明，睾酮可能与阿尔茨海默病（AD）的发病机制有关。我们旨在研究非痴呆老年人血浆总睾酮水平与脑葡萄糖代谢随时间变化之间的关系。
对非痴呆老年人血浆总睾酮水平与脑葡萄糖代谢变化之间的关联进行了横断面和纵向研究。鉴于血浆总睾酮水平在性别之间存在显著差异，我们按性别分层进行分析。基线时，纳入了228名非痴呆老年人：152名男性和76名女性。
在横断面分析中，未发现男性或女性的血浆总睾酮水平与脑葡萄糖代谢之间存在显著关系。在纵向分析中，我们发现男性血浆总睾酮水平与脑葡萄糖代谢随时间的变化存在显著关联，而女性则无此关联。更具体地说，在男性中，基线时血浆总睾酮水平较高与脑葡萄糖代谢下降较慢有关。
我们发现，基线时血浆总睾酮水平较高与无痴呆男性脑葡萄糖代谢下降较慢有关，这表明睾酮可能对脑功能具有有益作用。
