Helen Wills Neuroscience Institute, University of California-Berkeley, CA 94720-3190, USA.
Neurobiol Aging. 2011 Jul;32(7):1207-18. doi: 10.1016/j.neurobiolaging.2009.07.002. Epub 2009 Aug 5.
The Functional Activities Questionnaire (FAQ) and Alzheimer's Disease Assessment Scale-cognitive subscale (ADAS-cog) are frequently used indices of cognitive decline in Alzheimer's disease (AD). The goal of this study was to compare FDG-PET and clinical measurements in a large sample of elderly subjects with memory disturbance. We examined relationships between glucose metabolism in FDG-PET regions of interest (FDG-ROIs), and ADAS-cog and FAQ scores in AD and mild cognitive impairment (MCI) patients enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI). Low glucose metabolism at baseline predicted subsequent ADAS-cog and FAQ decline. In addition, longitudinal glucose metabolism decline was associated with concurrent ADAS-cog and FAQ decline. Finally, a power analysis revealed that FDG-ROI values have greater statistical power than ADAS-cog to detect attenuation of cognitive decline in AD and MCI patients. Glucose metabolism is a sensitive measure of change in cognition and functional ability in AD and MCI, and has value in predicting future cognitive decline.
功能活动问卷（FAQ）和阿尔茨海默病评估量表认知分量表（ADAS-cog）是常用于评估阿尔茨海默病（AD）认知能力下降的指标。本研究的目的是在有记忆障碍的大量老年受试者中比较 FDG-PET 和临床测量结果。我们研究了阿尔茨海默病神经影像学倡议（ADNI）中 AD 和轻度认知障碍（MCI）患者的 FDG-PET 感兴趣区（FDG-ROI）中的葡萄糖代谢与 ADAS-cog 和 FAQ 评分之间的关系。基线时葡萄糖代谢降低预示着随后 ADAS-cog 和 FAQ 的下降。此外，纵向葡萄糖代谢下降与同时的 ADAS-cog 和 FAQ 下降相关。最后，一项功效分析表明，与 ADAS-cog 相比，FDG-ROI 值在检测 AD 和 MCI 患者认知能力下降方面具有更大的统计学效力。葡萄糖代谢是 AD 和 MCI 认知和功能能力变化的敏感指标，在预测未来认知能力下降方面具有价值。
