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Editorial: Kv7 Channels: Structure, Physiology, and Pharmacology.

作者信息

Jepps Thomas A, Barrese Vincenzo, Miceli Francesco

机构信息

Vascular Biology Group, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

Department of Neuroscience, Reproductive Sciences and Dentistry, University of Naples Federico II, Naples, Italy.

出版信息

Front Physiol. 2021 Apr 16;12:679317. doi: 10.3389/fphys.2021.679317. eCollection 2021.

DOI:10.3389/fphys.2021.679317
PMID:33935812
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8085343/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2acd/8085343/700a2b1419e9/fphys-12-679317-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2acd/8085343/700a2b1419e9/fphys-12-679317-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2acd/8085343/700a2b1419e9/fphys-12-679317-g0001.jpg

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本文引用的文献

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KCNQ-Encoded Potassium Channels as Therapeutic Targets.KCNQ 编码钾通道作为治疗靶点。
Annu Rev Pharmacol Toxicol. 2018 Jan 6;58:625-648. doi: 10.1146/annurev-pharmtox-010617-052912. Epub 2017 Oct 6.
2
Kv7.1 ion channels require a lipid to couple voltage sensing to pore opening.Kv7.1 离子通道需要一种脂质将电压感应与孔道开放偶联起来。
Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):13180-5. doi: 10.1073/pnas.1305167110. Epub 2013 Jul 16.
3
KCNQ2 encephalopathy: emerging phenotype of a neonatal epileptic encephalopathy.
基于片段的离子通道相互作用分析的等温滴定量热法。
Methods Mol Biol. 2024;2796:271-289. doi: 10.1007/978-1-0716-3818-7_16.
4
A Developmental Switch in Cholinergic Mechanisms of Modulation in the Medial Nucleus of the Trapezoid Body.梯形体内侧髓体胆碱能调节机制的发育性转换。
J Neurosci. 2024 Feb 21;44(8):e0356232023. doi: 10.1523/JNEUROSCI.0356-23.2023.
5
Enteroendocrine cell regulation of the gut-brain axis.肠道内分泌细胞对肠-脑轴的调节。
Front Neurosci. 2023 Nov 7;17:1272955. doi: 10.3389/fnins.2023.1272955. eCollection 2023.
6
Mitochondrial Volume Regulation and Swelling Mechanisms in Cardiomyocytes.心肌细胞中的线粒体体积调节与肿胀机制
Antioxidants (Basel). 2023 Jul 28;12(8):1517. doi: 10.3390/antiox12081517.
7
KCNQ2 channels regulate the population activity of neonatal GABAergic neurons .KCNQ2通道调节新生期GABA能神经元的群体活动。
Front Neurol. 2023 Jun 20;14:1207539. doi: 10.3389/fneur.2023.1207539. eCollection 2023.
8
Molecular Insights Into Binding and Activation of the Human KCNQ2 Channel by Retigabine.瑞替加滨对人KCNQ2通道结合与激活的分子见解
Front Mol Biosci. 2022 Mar 3;9:839249. doi: 10.3389/fmolb.2022.839249. eCollection 2022.
9
Cannabidiol activates neuronal Kv7 channels.大麻二酚激活神经元 Kv7 通道。
Elife. 2022 Feb 18;11:e73246. doi: 10.7554/eLife.73246.
KCNQ2 脑病:一种新生儿癫痫性脑病的新表型。
Ann Neurol. 2012 Jan;71(1):15-25. doi: 10.1002/ana.22644.
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Mice with altered KCNQ4 K+ channels implicate sensory outer hair cells in human progressive deafness.KCNQ4钾离子通道发生改变的小鼠表明,感觉性外毛细胞与人类进行性耳聋有关。
EMBO J. 2006 Feb 8;25(3):642-52. doi: 10.1038/sj.emboj.7600951. Epub 2006 Jan 26.
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Experiments to test the role of phosphatidylinositol 4,5-bisphosphate in neurotransmitter-induced M-channel closure in bullfrog sympathetic neurons.测试磷脂酰肌醇4,5-二磷酸在牛蛙交感神经元中神经递质诱导的M通道关闭过程中作用的实验。
J Neurosci. 2003 Jun 15;23(12):4931-41. doi: 10.1523/JNEUROSCI.23-12-04931.2003.
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PIP(2) activates KCNQ channels, and its hydrolysis underlies receptor-mediated inhibition of M currents.磷脂酰肌醇-4,5-二磷酸(PIP(2))激活钾通道KCNQ,其水解是受体介导的M电流抑制的基础。
Neuron. 2003 Mar 27;37(6):963-75. doi: 10.1016/s0896-6273(03)00125-9.
8
KCNQ1 gene mutations and the respective genotype-phenotype correlations in the long QT syndrome.长QT综合征中的KCNQ1基因突变及其相应的基因型-表型相关性
Med Sci Monit. 2002 Oct;8(10):RA240-8.
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Molecular correlates of the M-current in cultured rat hippocampal neurons.培养的大鼠海马神经元中M电流的分子关联
J Physiol. 2002 Oct 1;544(Pt 1):29-37. doi: 10.1113/jphysiol.2002.028571.
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Recovery from muscarinic modulation of M current channels requires phosphatidylinositol 4,5-bisphosphate synthesis.M电流通道的毒蕈碱调节恢复需要磷脂酰肌醇4,5-二磷酸的合成。
Neuron. 2002 Aug 1;35(3):507-20. doi: 10.1016/s0896-6273(02)00790-0.