Witkiewicz K, Rykowski Z, Machoń Z, Lipnicka U, Burak K
Department of Organic Chemistry, Faculty of Pharmacy Medical Academy, Wrocław, Poland.
Pharmazie. 1988 Feb;43(2):84-6.
The synthesis of amino ketones and amino alcohols in p-menthane series is presented. These compounds were obtained in Mannich reaction, starting from the unsaturated ketone p-mentha-6,8-dien-2-one and its saturated analogue p-menthan-2-one. The structures of the compounds obtained were established by means of chemical transformations and elemental and spectral (IR, 1H NMR) analysis. The compounds obtained were subjected to the pharmacological investigations.
介绍了对薄荷烷系列中氨基酮和氨基醇的合成。这些化合物是通过曼尼希反应，从不饱和酮对薄荷-6,8-二烯-2-酮及其饱和类似物对薄荷烷-2-酮开始制得的。通过化学转化以及元素分析和光谱（红外光谱、核磁共振氢谱）分析确定了所得化合物的结构。对所得化合物进行了药理研究。
