Carroll R S, Weaver C E, Baum M J
Department of Biology, Boston University, MA 02215.
Physiol Behav. 1988;42(5):457-60. doi: 10.1016/0031-9384(88)90176-x.
We compared the effects of the aromatase inhibitor, 1,4,6-androstatriene-3,17-dione (ATD) and castration on the expression of mating behavior in adult male ferrets which were in breeding condition. Males implanted SC with Silastic capsules containing ATD displayed significantly less neck gripping, mounting and intromittive behavior than intact males which received empty capsules, although the ATD-induced reductions in behavior were not as large as those seen after castration. ATD had no effect on mating behavior in castrated males. As reported in another publication, brain aromatase activity was significantly reduced in both the intact and castrated males treated with ATD in the present study. Plasma estradiol (E2) levels were uniformly low in intact and castrated males, regardless of whether they received ATD or no steroid. As expected, plasma testosterone (T) levels were significantly lower in castrated than in intact males, and ATD treatment did not affect these values. These results suggest that E2 formed via the neural aromatization of T contributes to the activation of masculine sexual behavior in intact male ferrets in breeding condition.
我们比较了芳香化酶抑制剂1,4,6-雄甾三烯-3,17-二酮（ATD）和去势对处于繁殖状态的成年雄性雪貂交配行为表达的影响。皮下植入含ATD的硅橡胶胶囊的雄性雪貂，与接受空胶囊的完整雄性雪貂相比，颈部抓握、爬跨和插入行为显著减少，尽管ATD引起的行为减少程度不如去势后那么大。ATD对去势雄性雪貂的交配行为没有影响。正如另一篇出版物所报道的，在本研究中，接受ATD治疗的完整和去势雄性雪貂的脑芳香化酶活性均显著降低。无论完整和去势雄性雪貂是否接受ATD或未接受类固醇，其血浆雌二醇（E2）水平均一致较低。正如预期的那样，去势雄性雪貂的血浆睾酮（T）水平显著低于完整雄性雪貂，且ATD治疗不影响这些值。这些结果表明，通过睾酮的神经芳香化作用形成的E2有助于激活处于繁殖状态的完整雄性雪貂的雄性性行为。
