Arıcan Pinar, Bozkurt Oznur, Cavusoglu Dilek, Gencpınar Pinar, Haspolat Senay, Duman Ozgur, Olgac Dundar Nihal
Department of Pediatric Neurology, Izmir Tepecik Education and Research Hospital, Izmir, Turkey.
Department of Pediatric Neurology, Akdeniz University, Antalya, Turkey.
J Pediatr Neurosci. 2020 Oct-Dec;15(4):365-369. doi: 10.4103/jpn.JPN_130_19. Epub 2021 Jan 19.
Vitamin B12 deficiency occurs primarily as a result of insufficient dietary intake in children in developing countries. Vitamin B12 deficiency produces a cluster of neurological symptoms in children.
The aim of this study was to describe the vitamin B12 status of patients who were admitted with neurological symptoms and to evaluate the clinical response to vitamin B12 treatment.
This study was conducted on children who had vitamin B12 deficiency presented with neurological findings from January 2014 to October 2016. Patients with serum vitamin B12 levels lower than 300 pg/mL received intramuscular or oral vitamin B12 treatment.
Three hundred and fifty-one patients presenting with neurologic symptoms and who had low serum vitamin B12 deficiency were analyzed. Our study population was composed mainly of adolescent age. The most common symptom with respect to age was headache. In infant patients, most common symptoms were seizure and developmental delay.
Early diagnosis and vitamin B12 treatment are advocated to avoid long-term injury. Our study shows that patients with serum vitamin B12 levels lower than 300 pg/mL showed clinical improvement of neurological symptoms after receiving vitamin B12 treatment.
在发展中国家，儿童维生素B12缺乏主要是由于饮食摄入不足所致。维生素B12缺乏会在儿童中引发一系列神经症状。
本研究旨在描述因神经症状入院患者的维生素B12状况，并评估维生素B12治疗的临床反应。
本研究针对2014年1月至2016年10月出现神经学表现且存在维生素B12缺乏的儿童开展。血清维生素B12水平低于300 pg/mL的患者接受了肌肉注射或口服维生素B12治疗。
对351例出现神经症状且血清维生素B12水平低的患者进行了分析。我们的研究对象主要为青少年。就年龄而言，最常见的症状是头痛。在婴幼儿患者中，最常见的症状是癫痫发作和发育迟缓。
提倡早期诊断和维生素B12治疗以避免长期损伤。我们的研究表明，血清维生素B12水平低于300 pg/mL的患者在接受维生素B12治疗后神经症状有临床改善。
