Department of Pediatric Neurology, Harran University School of Medicine, 63200, Sanliurfa, Turkey.
Department of Pediatrics, Harran University School of Medicine, Sanliurfa, Turkey.
Neurol Sci. 2018 Jun;39(6):1009-1014. doi: 10.1007/s10072-018-3286-5. Epub 2018 Mar 8.
This study aimed to determine the relationship between serum vitamin B level and tension-type headache. The study groups consisted of 75 patients (40 females, 35 males) with headache and a control group of 49 healthy children (25 females, 24 males). Serum vitamin B level < 200 pg/ml was defined as deficient, and < 160 pg/ml as severely deficient. The serum vitamin B level was measured by the electrochemiluminescence (ECLIA) method. The serum vitamin B levels in the headache and control groups were 273.01 ± 76.77 and 316.22 ± 74.53 pg/ml, with the difference determined as statistically significant (p = 0.003). In the case group, 18/75 patients (24%) had a serum vitamin B12 level below the normal of 200 pg/ml, and in the control group 4/49 (8%) patients were also below the normal range (p = 0.021). The serum vitamin B level in the children with tension-type headache was significantly lower than that in the control group. From the results of the study, it was concluded that there may be an association between vitamin B level and tension-type headache. However, further clinical studies are needed.
本研究旨在确定血清维生素 B 水平与紧张型头痛之间的关系。研究组由 75 名头痛患者（40 名女性，35 名男性）和 49 名健康儿童对照组（25 名女性，24 名男性）组成。血清维生素 B 水平 <200pg/ml 定义为缺乏，<160pg/ml 定义为严重缺乏。血清维生素 B 水平通过电化学发光（ECLIA）法测量。头痛组和对照组的血清维生素 B 水平分别为 273.01 ± 76.77pg/ml 和 316.22 ± 74.53pg/ml，差异具有统计学意义（p=0.003）。在病例组中，18/75 名患者（24%）血清维生素 B12 水平低于 200pg/ml 的正常值，而对照组中也有 4/49 名患者（8%）低于正常值（p=0.021）。患有紧张型头痛的儿童的血清维生素 B 水平明显低于对照组。从研究结果来看，维生素 B 水平与紧张型头痛之间可能存在关联。但是，还需要进一步的临床研究。
