Guo Zhenfei, Liu Chang, Sun Jing, Zeng Linggong, Zhang Kai
Department of Stomatology, The First Affiliated Hospital of Bengbu Medical College 287 Chang Huai Road, Bengbu, Anhui, P. R. China.
Department of Microbiology, Bengbu Medical College 600 Dong Hai Avenue, Bengbu, Anhui, P. R. China.
Int J Clin Exp Pathol. 2021 Apr 15;14(4):533-537. eCollection 2021.
Castleman's disease is a very rare heterogeneous group of lymphoproliferative disorders characterized by non-neoplastic growths. It is unknown about the pathophysiology of the Castleman's disease. Previous studies demonstrated that Castleman's disease can be divided into two groups according to clinical classification, including unicentric Castleman disease (UCD) and multicentric Castleman disease (MCD). The hyaline vascular type is most common in the head and neck, and is abbreviated as UCD. In the present case, a woman complained that a mass in her parotid gland was growing and it was painless seven months ago. The computed tomography (CT) showed that the superficial lobe of the parotid gland on the left had an elliptical soft tissue density shadow, about 2.5×3.5 cm, with clear boundaries and no obvious abnormalities in the surrounding bone. The CT scan showed no obvious abnormalities in the shape and density of the right parotid and bilateral submandibular glands. After the operation, combined with the results of immunohistochemistry, the final diagnosis was Castleman tumor. The patient recovered smoothly, after the operation and during follow-up. The patient maintained good health without recurrence or metastasis.
卡斯特曼病是一组非常罕见的异质性淋巴增生性疾病,其特征为非肿瘤性生长。卡斯特曼病的病理生理学尚不清楚。先前的研究表明,根据临床分类,卡斯特曼病可分为两组,包括单中心卡斯特曼病(UCD)和多中心卡斯特曼病(MCD)。透明血管型在头颈部最为常见,简称为UCD。在本病例中,一名女性七个月前抱怨腮腺有一个肿块在生长且无痛。计算机断层扫描(CT)显示,左侧腮腺浅叶有一个椭圆形软组织密度影,约2.5×3.5厘米,边界清晰,周围骨质无明显异常。CT扫描显示右侧腮腺及双侧颌下腺的形态和密度无明显异常。手术后,结合免疫组化结果,最终诊断为卡斯特曼瘤。患者术后及随访期间恢复顺利。患者保持良好健康状态,无复发或转移。