Altun A, Hacimustafaoglu A M
Bahcesehir University, Department of Ophthalmology, Istanbul, Turkey.
VM Medical Park Goztepe Hospital, Clinic of Ophthalmology, Istanbul, Turkey.
J Ophthalmol. 2021 Apr 12;2021:8840689. doi: 10.1155/2021/8840689. eCollection 2021.
To investigate the change in subfoveal choroidal thickness (SFCT) in vitrectomized eyes with intravitreal dexamethasone (IVD) implant injection for the treatment of diabetic macular edema (DME).
In this prospective and controlled study, the vitrectomized eyes of diabetic patients were included. The study group (Group 1) was formed by diabetic vitrectomized eyes with DME. The control group (Group 2) was formed by diabetic vitrectomized eyes without DME. Only one intravitreal IVD implant was injected into the eyes in Group 1. In the first, second, and fourth months, choroidal layers were measured by optical coherence tomography and complete ophthalmologic examinations were performed for all cases.
Ninety-six eyes of 96 cases were included in the study. There were 48 eyes of 48 different patients in each group. After IVD injection, statistically significant improvement was observed in the best corrected visual acuity in Group 1. The mean SFCT in eyes with DME was statistically significantly thinner ( < 0.01) and thinness became more pronounced during the four-month follow-up period after IVD implant injection ( < 0.01).
In the presence of DME in vitrectomized eyes, the thinness of the SFCT may become evident after dexamethasone implant injection.
探讨玻璃体切除术后眼内注射地塞米松植入剂（IVD）治疗糖尿病性黄斑水肿（DME）时黄斑中心凹下脉络膜厚度（SFCT）的变化。
在这项前瞻性对照研究中，纳入糖尿病患者的玻璃体切除术后眼。研究组（第1组）由患有DME的糖尿病玻璃体切除术后眼组成。对照组（第2组）由无DME的糖尿病玻璃体切除术后眼组成。第1组的眼中仅注射一剂眼内地塞米松植入剂。在第1、2和4个月，通过光学相干断层扫描测量脉络膜层，并对所有病例进行全面的眼科检查。
96例患者的96只眼纳入研究。每组有48例不同患者的48只眼。注射IVD后，第1组的最佳矫正视力有统计学上的显著改善。患有DME的眼中平均SFCT在统计学上显著更薄（<0.01），并且在注射IVD植入剂后的4个月随访期内变薄更明显（<0.01）。
在玻璃体切除术后眼中存在DME的情况下，注射地塞米松植入剂后SFCT变薄可能会变得明显。
