Animal Nutritional Genome and Germplasm Innovation Research Center, College of Animal Science and Technology, Hunan Agricultural University, Changsha, China.
Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, China.
Front Cell Infect Microbiol. 2021 Apr 15;11:625210. doi: 10.3389/fcimb.2021.625210. eCollection 2021.
Diarrhea is a common problem to the whole world and the occurrence of diarrhea is highly associated with gut microbiota, such as bacteria, fungi, and viruses. Generally, diarrheal patients or animals are characterized by gut microbiota dysbiosis and pathogen infections may lead to diarrheal phenotypes. Of relevance, reprograming gut microbiota communities by dietary probiotics or fecal bacteria transplantation are widely introduced to treat or prevent diarrhea. In this review, we discussed the influence of the gut microbiota in the infection of diarrhea pathogens, and updated the research of reshaping the gut microbiota to prevent or treat diarrhea for the past few years. Together, gut microbiota manipulation is of great significance to the prevention and treatment of diarrhea, and further insight into the function of the gut microbiota will help to discover more anti-diarrhea probiotics.
腹泻是全世界普遍存在的问题，腹泻的发生与肠道微生物群高度相关，如细菌、真菌和病毒。一般来说，腹泻患者或动物的肠道微生物群失调，病原体感染可能导致腹泻表型。相关地，通过膳食益生菌或粪便细菌移植来重新编程肠道微生物群群落被广泛用于治疗或预防腹泻。在这篇综述中，我们讨论了肠道微生物群在腹泻病原体感染中的影响，并更新了近年来重塑肠道微生物群以预防或治疗腹泻的研究。总之，肠道微生物群的操纵对于预防和治疗腹泻具有重要意义，进一步深入了解肠道微生物群的功能将有助于发现更多的抗腹泻益生菌。
