• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

牛磺酸减弱亚牛磺酸诱导的结直肠癌ERK/RSK信号通路进展。

Taurine Attenuates the Hypotaurine-Induced Progression of CRC ERK/RSK Signaling.

作者信息

Hou Xiaodan, Hu Junwei, Zhao Xinyu, Wei Qing, Zhao Rongping, Li Min, Li Qiong

机构信息

Department of Laboratory Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.

Suzhou Institute of Systems Medicine, Center of Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, China.

出版信息

Front Cell Dev Biol. 2021 Apr 15;9:631163. doi: 10.3389/fcell.2021.631163. eCollection 2021.

DOI:10.3389/fcell.2021.631163
PMID:33937232
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8083965/
Abstract

Colorectal cancer (CRC) is one of the most common malignant tumors, and previous metabolomics work has demonstrated great promise in identifying specific small molecules of tumor phenotype. In the present study, we analyzed the metabolites of resected tissues through gas chromatography-mass spectrometry (GC-MS), and found that the concentration of taurine in CRC tissues diminished whereas the concentration of hypotaurine increased. The results demonstrated that taurine significantly suppressed cellular proliferation, metastasis, and colony formation whereas it induced apoptosis in CRC cells. Furthermore, taurine regulated the expression levels of epithelial mesenchymal transition (EMT)-associated genes in a dose-dependent manner. Taurine also alleviated hypotaurine-induced CRC progression, which was linked to the inhibition of the ERK/RSK-signaling pathway and diminution in intracellular hypotaurine. Taurine additionally attenuated hypotaurine-induced tumor growth and metastasis Patients with CRC exhibited lower levels of serum taurine, suggesting that taurine might be a promising biomarker reflecting a poor prognosis in CRC. Collectively, our results demonstrated that taurine-attenuated, hypotaurine-induced CRC progression provides a potential target for CRC therapy.

摘要

结直肠癌（CRC）是最常见的恶性肿瘤之一，先前的代谢组学研究已在识别肿瘤表型的特定小分子方面显示出巨大潜力。在本研究中，我们通过气相色谱 - 质谱联用（GC - MS）分析了切除组织的代谢物，发现CRC组织中牛磺酸浓度降低而次牛磺酸浓度升高。结果表明，牛磺酸显著抑制CRC细胞的增殖、转移和集落形成，同时诱导细胞凋亡。此外，牛磺酸以剂量依赖方式调节上皮 - 间质转化（EMT）相关基因的表达水平。牛磺酸还缓解了次牛磺酸诱导的CRC进展，这与抑制ERK/RSK信号通路和细胞内次牛磺酸减少有关。牛磺酸还减弱了次牛磺酸诱导的肿瘤生长和转移。CRC患者血清牛磺酸水平较低，提示牛磺酸可能是反映CRC预后不良的有前景的生物标志物。总体而言，我们的结果表明，牛磺酸减弱次牛磺酸诱导的CRC进展为CRC治疗提供了一个潜在靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33c9/8083965/c85f8cd84cd2/fcell-09-631163-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33c9/8083965/c78aab633d87/fcell-09-631163-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33c9/8083965/dfb4a5a34164/fcell-09-631163-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33c9/8083965/a3c5529a4a14/fcell-09-631163-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33c9/8083965/662a74662bd7/fcell-09-631163-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33c9/8083965/1d26412f1b6f/fcell-09-631163-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33c9/8083965/144efd2cca2d/fcell-09-631163-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33c9/8083965/999c066fed40/fcell-09-631163-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33c9/8083965/0e522c21163c/fcell-09-631163-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33c9/8083965/c85f8cd84cd2/fcell-09-631163-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33c9/8083965/c78aab633d87/fcell-09-631163-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33c9/8083965/dfb4a5a34164/fcell-09-631163-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33c9/8083965/a3c5529a4a14/fcell-09-631163-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33c9/8083965/662a74662bd7/fcell-09-631163-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33c9/8083965/1d26412f1b6f/fcell-09-631163-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33c9/8083965/144efd2cca2d/fcell-09-631163-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33c9/8083965/999c066fed40/fcell-09-631163-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33c9/8083965/0e522c21163c/fcell-09-631163-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/33c9/8083965/c85f8cd84cd2/fcell-09-631163-g009.jpg

相似文献

1
Taurine Attenuates the Hypotaurine-Induced Progression of CRC ERK/RSK Signaling.牛磺酸减弱亚牛磺酸诱导的结直肠癌ERK/RSK信号通路进展。
Front Cell Dev Biol. 2021 Apr 15;9:631163. doi: 10.3389/fcell.2021.631163. eCollection 2021.
2
Hypotaurine evokes a malignant phenotype in glioma through aberrant hypoxic signaling.次牛磺酸通过异常的缺氧信号传导在胶质瘤中诱发恶性表型。
Oncotarget. 2016 Mar 22;7(12):15200-14. doi: 10.18632/oncotarget.7710.
3
STC2 promotes the epithelial-mesenchymal transition of colorectal cancer cells through AKT-ERK signaling pathways.STC2通过AKT-ERK信号通路促进结肠癌细胞的上皮-间质转化。
Oncotarget. 2016 Nov 1;7(44):71400-71416. doi: 10.18632/oncotarget.12147.
4
c-Myb promotes growth and metastasis of colorectal cancer through c-fos-induced epithelial-mesenchymal transition.c-Myb 通过 c-fos 诱导的上皮间质转化促进结直肠癌的生长和转移。
Cancer Sci. 2019 Oct;110(10):3183-3196. doi: 10.1111/cas.14141. Epub 2019 Aug 13.
5
The long non-coding RNA TUG1 indicates a poor prognosis for colorectal cancer and promotes metastasis by affecting epithelial-mesenchymal transition.长链非编码RNA TUG1提示结直肠癌预后不良，并通过影响上皮-间质转化促进转移。
J Transl Med. 2016 Feb 8;14:42. doi: 10.1186/s12967-016-0786-z.
6
Hypotaurine is an Energy-Saving Hepatoprotective Compound against Ischemia-Reperfusion Injury of the Rat Liver.牛磺酸是一种节能的肝保护化合物，可对抗大鼠肝脏的缺血再灌注损伤。
J Clin Biochem Nutr. 2010 Mar;46(2):126-34. doi: 10.3164/jcbn.09-91. Epub 2010 Feb 27.
7
Gab2 facilitates epithelial-to-mesenchymal transition via the MEK/ERK/MMP signaling in colorectal cancer.Gab2通过MEK/ERK/MMP信号通路促进结直肠癌上皮-间质转化。
J Exp Clin Cancer Res. 2016 Jan 12;35:5. doi: 10.1186/s13046-015-0280-0.
8
HspB5 correlates with poor prognosis in colorectal cancer and prompts epithelial-mesenchymal transition through ERK signaling.热休克蛋白B5（HspB5）与结直肠癌的不良预后相关，并通过细胞外信号调节激酶（ERK）信号通路促使上皮-间质转化。
PLoS One. 2017 Aug 10;12(8):e0182588. doi: 10.1371/journal.pone.0182588. eCollection 2017.
9
negatively regulates the epithelial-to-mesenchymal transition in colorectal cancer through the Wnt signaling pathway.通过 Wnt 信号通路负调控结直肠癌中的上皮-间充质转化。
Am J Physiol Gastrointest Liver Physiol. 2020 May 1;318(5):G841-G853. doi: 10.1152/ajpgi.00178.2019. Epub 2020 Mar 9.
10
OVOL2, an Inhibitor of WNT Signaling, Reduces Invasive Activities of Human and Mouse Cancer Cells and Is Down-regulated in Human Colorectal Tumors.OVOL2，一种 WNT 信号通路的抑制剂，降低了人源和鼠源癌细胞的侵袭活性，并且在人结直肠肿瘤中下调。
Gastroenterology. 2016 Mar;150(3):659-671.e16. doi: 10.1053/j.gastro.2015.11.041. Epub 2015 Nov 24.

引用本文的文献

1
From colon wall to tumor niche: Unraveling the microbiome's role in colorectal cancer progression.从结肠壁到肿瘤微环境：解析微生物组在结直肠癌进展中的作用。
PLoS One. 2024 Oct 22;19(10):e0311233. doi: 10.1371/journal.pone.0311233. eCollection 2024.
2
Anoikis-related subtype and prognosis analyses based on bioinformatics, and an expression verification of ANGPTL4 based on experiments of lung adenocarcinoma.基于生物信息学的失巢凋亡相关亚型及预后分析，以及基于肺腺癌实验的ANGPTL4表达验证。
J Thorac Dis. 2024 Aug 31;16(8):5361-5378. doi: 10.21037/jtd-24-1123. Epub 2024 Aug 28.
3
Deciphering the impact of aggregated autophagy-related genes TUBA1B and HSP90AA1 on colorectal cancer evolution: a single-cell sequencing study of the tumor microenvironment.

本文引用的文献

1
Flavin-Containing Monooxygenase 1 Catalyzes the Production of Taurine from Hypotaurine.黄素单加氧酶 1 催化牛磺酸从牛磺脒生成。
Drug Metab Dispos. 2020 May;48(5):378-385. doi: 10.1124/dmd.119.089995. Epub 2020 Mar 10.
2
Extracellular-Signal Regulated Kinase: A Central Molecule Driving Epithelial-Mesenchymal Transition in Cancer.细胞外信号调节激酶：驱动癌症上皮间质转化的核心分子。
Int J Mol Sci. 2019 Jun 13;20(12):2885. doi: 10.3390/ijms20122885.
3
Cancer statistics, 2019.癌症统计数据，2019 年。
解析自噬相关基因TUBA1B和HSP90AA1聚集对结直肠癌进展的影响：肿瘤微环境的单细胞测序研究
Discov Oncol. 2024 Sep 11;15(1):431. doi: 10.1007/s12672-024-01322-4.
4
Colorectal cancer-specific microbiome in peripheral circulation and cancer tissues.外周循环和癌组织中结直肠癌特异性微生物群
Front Microbiol. 2024 Aug 21;15:1422536. doi: 10.3389/fmicb.2024.1422536. eCollection 2024.
5
The role of cytidine 5'-triphosphate synthetase 1 in metabolic rewiring during epithelial-to-mesenchymal transition in non-small-cell lung cancer.细胞质三磷酸尿苷合成酶 1 在非小细胞肺癌上皮-间充质转化代谢重编程中的作用。
FEBS Open Bio. 2024 Sep;14(9):1570-1583. doi: 10.1002/2211-5463.13860. Epub 2024 Jul 19.
6
Metabolomics Reveals Tyrosine Kinase Inhibitor Resistance-Associated Metabolic Events in Human Metastatic Renal Cancer Cells.代谢组学揭示了人类转移性肾癌细胞中酪氨酸激酶抑制剂耐药相关的代谢事件。
Int J Mol Sci. 2024 Jun 7;25(12):6328. doi: 10.3390/ijms25126328.
7
Identification of crucial inflammaging related risk factors in multiple sclerosis.多发性硬化症中关键的炎症衰老相关风险因素的识别
Front Mol Neurosci. 2024 May 21;17:1398665. doi: 10.3389/fnmol.2024.1398665. eCollection 2024.
8
Metabolomic and Lipidomic Analysis of the Colorectal Adenocarcinoma Cell Line HT29 in Hypoxia and Reoxygenation.缺氧和复氧条件下结直肠腺癌细胞系HT29的代谢组学和脂质组学分析
Metabolites. 2023 Jul 23;13(7):875. doi: 10.3390/metabo13070875.
9
Systematic Review: Contribution of the Gut Microbiome to the Volatile Metabolic Fingerprint of Colorectal Neoplasia.系统评价：肠道微生物群对结直肠癌挥发性代谢指纹图谱的贡献
Metabolites. 2022 Dec 30;13(1):55. doi: 10.3390/metabo13010055.
10
Metabolic reprogramming enables the auxiliary diagnosis of breast cancer by automated breast volume scanner.代谢重编程可通过自动乳腺容积扫描仪实现乳腺癌的辅助诊断。
Front Oncol. 2022 Oct 12;12:939606. doi: 10.3389/fonc.2022.939606. eCollection 2022.
CA Cancer J Clin. 2019 Jan;69(1):7-34. doi: 10.3322/caac.21551. Epub 2019 Jan 8.
4
Taurine exhibits an apoptosis-inducing effect on human nasopharyngeal carcinoma cells through PTEN/Akt pathways in vitro.牛磺酸通过体外 PTEN/Akt 通路诱导人鼻咽癌细胞凋亡。
Amino Acids. 2018 Dec;50(12):1749-1758. doi: 10.1007/s00726-018-2651-2. Epub 2018 Sep 17.
5
Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries.全球癌症统计数据 2018：GLOBOCAN 对全球 185 个国家/地区 36 种癌症的发病率和死亡率的估计。
CA Cancer J Clin. 2018 Nov;68(6):394-424. doi: 10.3322/caac.21492. Epub 2018 Sep 12.
6
Effect of taurine on cell proliferation and apoptosis human lung cancer A549 cells.牛磺酸对人肺癌A549细胞增殖和凋亡的影响。
Oncol Lett. 2018 Apr;15(4):5473-5480. doi: 10.3892/ol.2018.8036. Epub 2018 Feb 13.
7
Prediction of Chemotherapeutic Efficacy in Non-Small Cell Lung Cancer by Serum Metabolomic Profiling.基于血清代谢组学分析预测非小细胞肺癌的化疗疗效。
Clin Cancer Res. 2018 May 1;24(9):2100-2109. doi: 10.1158/1078-0432.CCR-17-2855. Epub 2018 Feb 6.
8
Muscle proteolytic system modulation through the effect of taurine on mice bearing muscular atrophy.通过牛磺酸对肌肉萎缩小鼠的作用调节肌肉蛋白水解系统。
Mol Cell Biochem. 2018 Jul;444(1-2):161-168. doi: 10.1007/s11010-017-3240-5. Epub 2017 Dec 2.
9
Taurine as an Essential Neuromodulator during Perinatal Cortical Development.牛磺酸作为围产期皮质发育过程中的一种必需神经调节剂。
Front Cell Neurosci. 2017 Oct 24;11:328. doi: 10.3389/fncel.2017.00328. eCollection 2017.
10
Serum Metabolomic Profiles for Breast Cancer Diagnosis, Grading and Staging by Gas Chromatography-Mass Spectrometry.基于气相色谱-质谱联用的血清代谢组学在乳腺癌诊断、分级和分期中的应用
Sci Rep. 2017 May 11;7(1):1715. doi: 10.1038/s41598-017-01924-9.