Zhi Yiqiang, Zhou Xiaokun, Yu Jurui, Yuan Ling, Zhang Hongsheng, Ng Dominic C H, Xu Zhiheng, Xu Dan
College of Biological Science and Engineering, Institute of Life Sciences, Fuzhou University, Fuzhou, China.
Center for Medical Genetics, School of Life Sciences, Central South University, Changsha, China.
Front Cell Dev Biol. 2021 Apr 16;9:640753. doi: 10.3389/fcell.2021.640753. eCollection 2021.
The c-Jun N-terminal kinase (JNK) is highly evolutionarily conserved and plays important roles in a broad range of physiological and pathological processes. The WD40-repeat protein 62 (WDR62) is a scaffold protein that recruits different components of the JNK signaling pathway to regulate several human diseases including neurological disorders, infertility, and tumorigenesis. Recent studies revealed that WDR62 regulates the process of neural stem cell mitosis and germ cell meiosis through JNK signaling. In this review we summarize the roles of WDR62 and JNK signaling in neuronal and non-neuronal contexts and discuss how JNK-dependent signaling regulates both processes. WDR62 is involved in various human disorders JNK signaling regulation, and may represent a promising therapeutic strategy for the treatment of related diseases.
c-Jun氨基末端激酶（JNK）在进化上高度保守，在广泛的生理和病理过程中发挥重要作用。WD40重复蛋白62（WDR62）是一种支架蛋白，可募集JNK信号通路的不同组分，以调节包括神经疾病、不孕症和肿瘤发生在内的多种人类疾病。最近的研究表明，WDR62通过JNK信号传导调节神经干细胞有丝分裂和生殖细胞减数分裂过程。在本综述中，我们总结了WDR62和JNK信号在神经元和非神经元环境中的作用，并讨论了JNK依赖性信号如何调节这两个过程。WDR62参与各种人类疾病的JNK信号调节，可能是治疗相关疾病的一种有前景的治疗策略。
