Li Jie, Wei Wenjie, Xu Feng, Wang Yuanyi, Liu Yadong, Fu Changfeng
Department of Spine Surgery, The First Hospital of Jilin University, Changchun, China.
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China.
Front Surg. 2021 Apr 15;8:626873. doi: 10.3389/fsurg.2021.626873. eCollection 2021.
Metastatic spinal tumors (MST) have high rates of morbidity and mortality. MST can destroy the vertebral body or compress the nerve roots, resulting in an increased risk of pathological fractures and intractable pain. Here, we elaborately reviewed the currently available therapeutic options for MST according to the following four aspects: surgical management, minimally invasive therapy (MIT), radiation therapy, and systemic therapy. In particular, these aspects were classified and introduced to show their developmental process, clinical effects, advantages, and current limitations. Furthermore, with the improvement of treatment concepts and techniques, we discovered the prevalent trend toward the use of radiation therapy and MIT in clinic therapies. Finally, the future directions of these treatment options were discussed. We hoped that along with future advances and study will lead to the improvement of living standard and present status of treatment in patients with MST.
转移性脊柱肿瘤（MST）的发病率和死亡率很高。MST可破坏椎体或压迫神经根，导致病理性骨折和顽固性疼痛的风险增加。在此，我们根据手术治疗、微创治疗（MIT）、放射治疗和全身治疗这四个方面，精心回顾了目前可用于MST的治疗选择。特别是，对这些方面进行了分类和介绍，以展示其发展过程、临床效果、优势和当前局限性。此外，随着治疗理念和技术的改进，我们发现了临床治疗中使用放射治疗和MIT的普遍趋势。最后，讨论了这些治疗选择的未来方向。我们希望随着未来的进展和研究，将改善MST患者的生活水平和治疗现状。
