Wu Xiaoyun, Liang Dongjie, Sun Junfang, Lin Yanyan, Wu Shengjie
Department of Rehabilitation, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Front Cardiovasc Med. 2021 Apr 16;8:644044. doi: 10.3389/fcvm.2021.644044. eCollection 2021.
Higher serum gamma-glutamyltransferase (GGT) is associated with high risk of hypertension. We aimed to examine the association between sex-specific serum GGT levels and incident of hypertension in a Chinese population without metabolic syndrome. Participants who were free of hypertension and metabolic syndrome from the First Affiliated Hospital of Wenzhou Medical University between 2009 and 2014 were included. Participants were grouped into sex-specific quartiles of GGT levels (Q1-Q4) defined as: ≤19, 20-26, 27-38, and ≥39 U/L for male; ≤12, 13-15, 16-19, and ≥20 U/L for female. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for incidence of hypertension according to sex-specific quartiles of GGT levels. Kaplan-Meier analysis and interaction analysis were conducted. Among 38,806 participants included (average age 36.0 years, 54.0% men), 4,505 of them developed hypertension. In the overall study population, using Q1 as the reference group, participants in Q2, Q3, and Q4 showed a higher risk of developing hypertension, with HRs (95% CIs) of 1.126 (1.029-1.232), 1.187 (1.083-1.302), and 1.300 (1.182-1.431), respectively ( < 0.001), after adjusting for known confounders. Sex-specific analysis showed that the adjusted HRs for participants in Q4 (reference: Q1) were greater in females [1.321 (1.100-1.586, < 0.001)] than in males [1.268 (1.133-1.420, < 0.001)] ( for interaction = 0.047). Moreover, interaction analysis showed that this association was consistently observed when the participants were stratified by age, body mass index, and fatty liver status. Among Chinese adults without metabolic syndrome, serum GGT level was positively associated with incidence of hypertension, and the association was stronger in females than in males.
血清γ-谷氨酰转移酶（GGT）水平升高与高血压高风险相关。我们旨在研究在中国无代谢综合征人群中，按性别划分的血清GGT水平与高血压发病之间的关联。纳入了2009年至2014年期间温州医科大学附属第一医院无高血压和代谢综合征的参与者。参与者按性别分为GGT水平的四分位数组（Q1-Q4），定义为：男性≤19、20-26、27-38和≥39 U/L；女性≤12、13-15、16-19和≥20 U/L。使用Cox比例风险模型根据按性别划分的GGT水平四分位数估计高血压发病的风险比（HRs）和95%置信区间（CIs）。进行了Kaplan-Meier分析和交互作用分析。在纳入的38806名参与者中（平均年龄36.0岁，男性占54.0%），其中4505人患高血压。在总体研究人群中，以Q1作为参照组，调整已知混杂因素后，Q2、Q3和Q4组的参与者患高血压的风险更高，HRs（95% CIs）分别为1.126（1.029-1.232）、1.187（1.083-1.302）和1.300（1.182-1.431）（P<0.001）。按性别分析显示，Q4组参与者（参照：Q1）的校正HRs在女性中[1.321（1.100-1.586，P<0.001）]高于男性[1.268（1.133-1.420，P<0.001）]（交互作用P = 0.047）。此外，交互作用分析显示，当按年龄、体重指数和脂肪肝状态对参与者进行分层时，这种关联始终存在。在中国无代谢综合征的成年人中，血清GGT水平与高血压发病呈正相关，且女性中的关联强于男性。
