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切开复位内固定术(ORIF)与切开复位内固定术联合一期距下关节融合术治疗复杂移位关节内跟骨骨折:期望值决策分析

Open reduction and internal fixation (ORIF) versus ORIF and primary subtalar arthrodesis for complex displaced intraarticular calcaneus fractures: An expected value decision analysis.

作者信息

Eisenstein Emmanuel David, Kusnezov Nicholas A, Waterman Brian R, Orr Justin D, Blair James A

机构信息

William Beaumont Army Medical Center, Department of Orthopaedics, N Piedras, El Paso, TX.

出版信息

OTA Int. 2020 Sep 13;1(2):e005. doi: 10.1097/OI9.0000000000000005. eCollection 2018 Sep.

Abstract

OBJECTIVES

To determine the optimal patient-oriented treatment between open reduction and internal fixation (ORIF) with or without primary subtalar arthrodesis (PSTA) for patients with displaced intraarticular calcaneus fractures (DIACFs, OTA 82-C3 and C4).

DESIGN

Expected value decision analysis.

SETTING

Academic military treatment facility.

PARTICIPANTS

One hundred randomly selected volunteers.

INTERVENTION

Hypothetical clinical scenario involving ORIF versus ORIF with PSTA.

MAIN OUTCOME MEASUREMENTS

Decision analysis was used to elucidate the superior treatment option based on expected patient values, composed of: the product of the average outcome probabilities established by previously published studies and the average ascribed patient utility values for each outcome probability. One-way sensitivity analysis was performed to quantify the amount of change required for the inferior treatment to equal or surpass the superior option.

RESULTS

Expected values for ORIF and ORIF with PSTA were 8.96 and 18.06, respectively, favoring ORIF with PSTA. One-way sensitivity analysis was performed by artificially decreasing the rate of secondary fusion following isolated ORIF thus increasing its overall expected value. Adjusting the rate of secondary fusion to 0%, the expected value of ORIF with PSTA nearly doubled that of ORIF (18.06 vs 9.45). Similarly, when adjusting the moderate and severe complication rates following ORIF with PSTA to 100%, the expected value of ORIF with PSTA still exceeded that of ORIF (15.45 vs 8.96, and 13.52 vs 8.96, respectively).

CONCLUSION

Expected value decision analysis favors ORIF with PSTA as the optimal treatment for complex DIACF.

摘要

目的

确定对于移位的关节内跟骨骨折(DIACF,OTA 82 - C3和C4)患者,在切开复位内固定(ORIF)联合或不联合一期距下关节融合术(PSTA)的情况下,以患者为导向的最佳治疗方案。

设计

期望值决策分析。

地点

学术性军事治疗机构。

参与者

100名随机选取的志愿者。

干预

涉及ORIF与ORIF联合PSTA的假设临床情景。

主要测量指标

采用决策分析,根据预期患者值阐明更佳的治疗方案,预期患者值由以下两部分组成:先前发表的研究确定的平均结局概率与每个结局概率对应的平均患者效用值的乘积。进行单向敏感性分析,以量化较差治疗方案达到或超过更佳方案所需的变化量。

结果

ORIF和ORIF联合PSTA的期望值分别为8.96和18.06,支持ORIF联合PSTA。通过人为降低单纯ORIF后的二次融合率来进行单向敏感性分析,从而提高其总体期望值。将二次融合率调整为0%时,ORIF联合PSTA的期望值几乎是ORIF的两倍(18.06对9.45)。同样,当将ORIF联合PSTA后的中度和重度并发症发生率调整为100%时,ORIF联合PSTA的期望值仍超过ORIF(分别为15.45对8.96以及13.52对8.96)。

结论

期望值决策分析支持ORIF联合PSTA作为复杂DIACF的最佳治疗方案。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/69fa/7953466/b58f112221b1/oi9-1-e005-g001.jpg

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