Division of Allergy, Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Ankara Child Health and Disease Hematology, Oncology Education and Research Hospital, Altindag, Ankara, Turkey.
Allergol Immunopathol (Madr). 2021 May 1;49(3):162-168. doi: 10.15586/aei.v49i3.191. eCollection 2021.
Several markers that influence the clinical course of atopic dermatitis (AD) have been investigated so far. Thymus and activation regulated chemokine (TARC) - a Th2-related cytokine - increase in various atopic diseases. It has been shown that vitamin D affects Treg cells and immune responses. Zinc as an essential trace element for cell-cell interactions, cellular differentiation, and proliferation. However, the effect of these markers on infantile AD and disease severity are mostly unknown.
The aim of this study was to investigate the relationship between TARC, vitamin D, zinc levels, and the disease severity in infants with AD.
AD patients (n = 160) with age and sex that matched healthy controls (n = 79) were included in the study. The diagnosis of AD was made based on the Hanifin-Rajka criteria. The objective SCORAD index was used for the assessment of disease severity.
A total of 160 patients (male 71.9%) with AD were included in the study. The median age of onset of symptoms was 2 (1.0-3.5) months. The lesions initially started on face 76.9%, neck 6.9%, extremities 7.5%, and body 8.8%. Nearly 40% of the patients were found to be atopic. Food allergy was found in 39.4%. The median of objective SCORAD index was 27.5 (17.5-40) in the study group. The TARC levels of AD patients were higher than control group [1803 pg/ml (1006- 3123) vs 709 pg/ml (504-1147), p < 0.001] There was a significant correlation between objective SCORAD scores and TARC values in subjects with AD (r = 0.363, p < 0.001). As the severity of AD increased, vitamin D levels decreased (p for trend 0.015) and TARC values increased (p for trend < 0.001). Serum zinc levels did not change with the severity of the disease. The presence of atopy did not have an influence on serum TARC, zinc, and vitamin D levels.
In infants with AD, disease severity is positively related with TARC levels; and inversely proportional to vitamin D levels. TARC levels differ between patients and healthy controls. The presence of atopy has not been shown to affect these markers. © 2021 Codon Publications. Published by Codon Publications.
迄今为止，已经研究了许多影响特应性皮炎（AD）临床病程的标志物。胸腺激活调节趋化因子（TARC）-一种与 Th2 相关的细胞因子-在各种特应性疾病中增加。已经表明维生素 D 影响 Treg 细胞和免疫反应。锌作为细胞-细胞相互作用、细胞分化和增殖的必需痕量元素。然而，这些标志物对婴儿 AD 和疾病严重程度的影响在很大程度上尚不清楚。
本研究旨在探讨 TARC、维生素 D、锌水平与 AD 婴儿疾病严重程度之间的关系。
纳入年龄和性别与健康对照组相匹配的 AD 患者（n=160）和健康对照组（n=79）。AD 的诊断基于 Hanifin-Rajka 标准。使用客观 SCORAD 指数评估疾病严重程度。
共纳入 160 例（男 71.9%）AD 患者。症状发作的中位年龄为 2（1.0-3.5）个月。病变最初开始于面部 76.9%、颈部 6.9%、四肢 7.5%和身体 8.8%。近 40%的患者有特应性。发现食物过敏 39.4%。研究组的客观 SCORAD 指数中位数为 27.5（17.5-40）。AD 患者的 TARC 水平高于对照组[1803pg/ml（1006-3123）比 709pg/ml（504-1147），p<0.001]。AD 患者的客观 SCORAD 评分与 TARC 值之间存在显著相关性（r=0.363，p<0.001）。随着 AD 严重程度的增加，维生素 D 水平下降（趋势 p 值为 0.015），TARC 值升高（趋势 p 值<0.001）。血清锌水平与疾病严重程度无关。特应性的存在对血清 TARC、锌和维生素 D 水平没有影响。
在患有 AD 的婴儿中，疾病严重程度与 TARC 水平呈正相关；与维生素 D 水平成反比。TARC 水平在患者和健康对照组之间存在差异。特应性的存在并未显示影响这些标志物。© 2021 Codon Publications。由 Codon Publications 出版。
