Tuppurainen M, Wägar G, Kurppa K, Sakari W, Wambugu A, Fröseth B, Alho J, Nykyri E
Institute of Occupational Health, Helsinki, Finland.
Scand J Work Environ Health. 1988 Jun;14(3):175-80. doi: 10.5271/sjweh.1934.
Thyroid function was studied in 176 male workers occupationally exposed to lead. The mean blood lead concentration of the workers was 2.70 (SD 1.15, range 0.70-6.45) mumol/l. The mean duration of lead exposure was 7.6 (range 0.1-20) years. The total thyroxine (T4), free thyroxine (FT4), total triiodothyronine (T3), and thyrotropin concentrations in serum were similar in the workers in the low and high blood lead categories. In regression equations the duration of lead exposure had a weak but significant negative association with T4 and FT4, and this association was particularly pronounced when the analyses were restricted to workers with the most intense lead exposure over time. Thus, the results suggest that thyroid function might be depressed as a result of intense long-term lead exposure.
对176名职业性接触铅的男性工人的甲状腺功能进行了研究。这些工人的平均血铅浓度为2.70（标准差1.15，范围0.70 - 6.45）μmol/l。铅暴露的平均时长为7.6（范围0.1 - 20）年。血铅水平低和高的两组工人血清中的总甲状腺素（T4）、游离甲状腺素（FT4）、总三碘甲状腺原氨酸（T3）和促甲状腺激素浓度相似。在回归方程中，铅暴露时长与T4和FT4呈弱但显著的负相关，当分析仅限于长期铅暴露最严重的工人时，这种相关性尤为明显。因此，结果表明长期高强度铅暴露可能会抑制甲状腺功能。
