Siegel M, Forsyth B, Siegel L, Cullen M R
Occupational Medicine Program, Yale University School of Medicine, New Haven, Connecticut 06510.
Environ Res. 1989 Aug;49(2):190-6. doi: 10.1016/s0013-9351(89)80064-7.
Exposure to inorganic lead has been associated with impaired uptake of iodine by the thyroid as well as depressed estimated free thyroxine levels in occupationally exposed adults. Consideration of the serious consequences of impaired thyroid function in young children prompted investigation of the effects of lead on thyroid function in children. Blood lead determinations and thyroid function tests were performed on 68 children examined at a hospital outpatient pediatric clinic. Serum thyroxine (T4) and free thyroxine (FT4) levels were within the normal range for all patients. No statistically significant relationship was found between lead levels and T4 or FT4 levels. We conclude that lead is unlikely to have a clinically significant effect on thyroid function in children exposed in inner cities at prevailing levels.
接触无机铅与职业暴露的成年人甲状腺碘摄取受损以及估计的游离甲状腺素水平降低有关。鉴于幼儿甲状腺功能受损会产生严重后果，因此对铅对儿童甲状腺功能的影响展开了调查。对一家医院门诊儿科诊所检查的68名儿童进行了血铅测定和甲状腺功能测试。所有患者的血清甲状腺素（T4）和游离甲状腺素（FT4）水平均在正常范围内。未发现铅水平与T4或FT4水平之间存在统计学上的显著关系。我们得出结论，在当前水平下，铅不太可能对城市中心地区接触铅的儿童甲状腺功能产生临床显著影响。
