Jogi Reena, Tager Mark J, Perez Diego, Tsapekos Menelaos
J Drugs Dermatol. 2021 May 1;20(5):538-545. doi: 10.36849/JDD.5851.
Applied topically, growth factors, cytokines, and other components in bovine colostrum are known to affect collagen biosynthesis, thus offering promise as a therapeutic modality in wound healing, delay in skin aging, and skin rejuvenation.
To demonstrate the protective effect that liposomal bovine colostrum exerts on skin aging using telomere length as an aging biomarker.
Human fibroblasts were cultured for 8 weeks with colostrum at three concentrations (0.125%, 0.25%, 0.50%). Cells were cultured and assayed both under standard conditions, as well as with H2O2 added as an agent of oxidative stress. Alterations in proliferation rates, telomere lengths, and telomere shortening rates (TSRs) were determined in each treatment group and compared.
Colostrum increased the proliferation rate of the fibroblast control cells and the addition of H2O2(without colostrum) decreased the proliferation rates of the fibroblast control cells. Under standard culture conditions, telomeres shortened progressively over 8 weeks and the addition of colostrum reduced the rate of telomere shortening. Under oxidative stress conditions (H2O2 – induced) the TSR increased; however, treatment with colostrum appeared to attenuate this increase.
Under normal culture conditions and after both 4 weeks and 8 weeks of treatment, liposomal bovine colostrum appears to exert a protective effect on telomere length erosion. Under culture conditions of oxidative stress and after 8 weeks of treatment, colostrum appears to exert a protective effect on telomere length erosion. These results suggest that topical treatment of the liposomal bovine colostrum formulation would enhance skin health as the skin ages. J Drugs Dermatol. 20(5):538-545. doi:10.36849/JDD.5851.
已知局部应用牛初乳中的生长因子、细胞因子和其他成分会影响胶原蛋白的生物合成，因此有望成为伤口愈合、延缓皮肤衰老和皮肤年轻化的治疗方式。
以端粒长度作为衰老生物标志物，证明脂质体牛初乳对皮肤衰老的保护作用。
将人成纤维细胞用三种浓度（0.125%、0.25%、0.50%）的初乳培养8周。细胞在标准条件下以及添加过氧化氢作为氧化应激剂的情况下进行培养和检测。测定每个治疗组的增殖率、端粒长度和端粒缩短率（TSR）变化并进行比较。
初乳提高了成纤维细胞对照细胞的增殖率，添加过氧化氢（无初乳）降低了成纤维细胞对照细胞的增殖率。在标准培养条件下，端粒在8周内逐渐缩短，添加初乳降低了端粒缩短率。在氧化应激条件下（过氧化氢诱导）TSR增加；然而，初乳治疗似乎减弱了这种增加。
在正常培养条件下以及治疗4周和8周后，脂质体牛初乳似乎对端粒长度侵蚀具有保护作用。在氧化应激培养条件下以及治疗8周后，初乳似乎对端粒长度侵蚀具有保护作用。这些结果表明，脂质体牛初乳制剂的局部治疗将随着皮肤衰老而增强皮肤健康。《药物皮肤病学杂志》。20(5):538 - 545。doi:10.36849/JDD.5851。
