Department of Molecular Biology and Genetics, Çanakkale Onsekiz Mart University, Canakkale 17000, Türkiye.
Laboratorio de Higiene Inspección y Control de Alimentos, Departamento de Química Analítica, Nutrición y Bromatología, Universidade de Santiago de Compostela, Campus Terra, 27002 Lugo, Spain.
Nutrients. 2024 Jul 21;16(14):2359. doi: 10.3390/nu16142359.
Colostrum is a nutritious milk synthesized by mammals during the postpartum period, and its rich bioactive components has led to a global increase in the consumption of bovine colostrum as a supplement. Bovine colostrum contains key components such as immunoglobulins, oligosaccharides, lactoferrin and lysozyme. It is a special supplement source due to its natural, high bioavailability and high concentrations of growth factors. Growth factors are critical to many physiological functions, and considering its presence in the colostrum, further research must be conducted on its safe application in many bodily disorders. Growth factors contribute to wound healing, muscle and bone development, and supporting growth in children. Additionally, the molecular mechanisms have been explored, highlighting the growth factors roles in cell proliferation, tissue regeneration, and the regulation of immune responses. These findings are crucial for understanding the potential health effects of bovine colostrum, ensuring its safe use, and forming a basis for future clinical applications. This review article examines the growth factors concentration in bovine colostrum, their benefits, clinical studies, and molecular mechanisms.
初乳是哺乳动物在产后期间合成的一种营养丰富的奶,其丰富的生物活性成分导致全球对牛初乳作为补充剂的消费增加。牛初乳含有免疫球蛋白、寡糖、乳铁蛋白和溶菌酶等关键成分。由于其天然、高生物利用度和高浓度的生长因子,它是一种特殊的补充剂来源。生长因子对许多生理功能至关重要,考虑到它在初乳中的存在,必须对其在许多身体疾病中的安全应用进行进一步研究。生长因子有助于伤口愈合、肌肉和骨骼发育以及儿童的生长。此外,还探索了分子机制,强调了生长因子在细胞增殖、组织再生和免疫反应调节中的作用。这些发现对于理解牛初乳的潜在健康影响、确保其安全使用以及为未来的临床应用奠定基础至关重要。本文综述了牛初乳中生长因子的浓度、它们的益处、临床研究和分子机制。