College of Food Engineering and Nutritional Science, Shaanxi Normal University, Xi'an 710119, P. R. China.
School of Food and Biological Engineering, Shaanxi University of Science and Technology, Xi'an 710021, P. R. China.
J Agric Food Chem. 2021 May 12;69(18):5297-5305. doi: 10.1021/acs.jafc.1c02117. Epub 2021 May 3.
Global health concerns are clearly evidenced by cardiovascular disease, kidney damage, and heart attacks. Antihypertensive synthetic drugs, including angiotensin-converting enzyme (ACE) inhibitors, effectively control hypertension but with unpleasant side effects. In recent decades, studies on the role of food-derived compounds have provided a positive contribution to ACE regulation. Here, the research progress of plant food-derived phenolic compounds as ACE inhibitors is reviewed. A survey of bioactive compounds of plant food is presented to broaden the source scope of natural ACE inhibitors. A consecutive understanding of plant-derived ACE inhibitors classification, inhibition mechanism, structure-activity relationship, and bioavailability are scientifically organized. The emerging evidence highlights areas that need further research, including those related to molecular structure, bioaccessibility, and interactions with gut microflora. Future research on such topics may encourage basic research and clinic application to exploit these plant food constituents as novel ACE inhibitors.
全球健康问题明显表现在心血管疾病、肾脏损伤和心脏病发作上。抗高血压合成药物，包括血管紧张素转换酶 (ACE) 抑制剂，能有效地控制高血压，但有不良反应。近几十年来，对食物衍生化合物作用的研究为 ACE 调节提供了积极贡献。本文综述了植物源性酚类化合物作为 ACE 抑制剂的研究进展。对植物源性食品的生物活性化合物进行了调查，以拓宽天然 ACE 抑制剂的来源范围。对植物源性 ACE 抑制剂的分类、抑制机制、构效关系和生物利用度进行了科学组织。新出现的证据强调了需要进一步研究的领域，包括与分子结构、生物利用度和与肠道微生物群相互作用相关的领域。对这些课题的未来研究可能会鼓励基础研究和临床应用，以开发这些植物性食品成分作为新型 ACE 抑制剂。
