Department of Infectious Diseases, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran.
Department of Infectious Diseases, Faculty of Medicine, Qom University of Medical Sciences, Qom, Iran.
Int J Infect Dis. 2021 Jun;107:264-267. doi: 10.1016/j.ijid.2021.04.083. Epub 2021 Apr 30.
Since the beginning of the Coronavirus disease 2019 (COVID-19) pandemic there have been contradictions and speculations about the relationship between vitamin D and COVID-19. Given that there is an association between vitamin D deficiency and some diseases - including cancer, autoimmune disease and some infectious diseases - a higher incidence and mortality rate in the vitamin-D-deficient COVID-19 population was not a surprise; conversely, some research would argue this relationship. Considering these contradictions, this study aimed to determine the relationship between prognosis and vitamin D level in cases with COVID-19.
In this cross-sectional study, 329 confirmed cases of COVID-19 - who were admitted to Kamkar-ArabNia Hospital in Qom city, Iran from March-July 2020 - were categorized into three groups according to vitamin D serum levels (ng/ml): sufficient (>30), insufficient (20-30) and deficient (<20). Prognosis was determined across the groups.
There was a significant difference in hospital stay between patients with sufficient and insufficient vitamin D levels (P = 0.007). Adjusting vitamin D levels for confounding variables, linear regression underscored significant differences in the association between length of hospitalization and lower vitamin D levels, with a longer stay noted in insufficient groups (P = 0.002). However, there was no significant difference in the time interval to return to normal oxygen level (from SpO2 < 93%) or death rate between groups (P > 0.05).
There was a significant association between hospital stay and lower serum vitamin D levels. However, the relationship between vitamin D status and death rate or the time interval to return to normal oxygen levels was not significant.
自 2019 年冠状病毒病（COVID-19）大流行开始以来，关于维生素 D 与 COVID-19 之间的关系一直存在矛盾和猜测。鉴于维生素 D 缺乏与一些疾病（包括癌症、自身免疫性疾病和一些传染病）之间存在关联，在维生素 D 缺乏的 COVID-19 人群中发病率和死亡率较高并不奇怪；相反，一些研究则认为这种关系是相反的。考虑到这些矛盾，本研究旨在确定 COVID-19 患者预后与维生素 D 水平之间的关系。
在这项横断面研究中，将 2020 年 3 月至 7 月期间在伊朗库姆市卡姆卡-阿拉布尼亚医院住院的 329 例确诊 COVID-19 病例根据血清维生素 D 水平（ng/ml）分为三组：充足（>30）、不足（20-30）和缺乏（<20）。评估各组的预后。
在维生素 D 水平充足和不足的患者之间，住院时间存在显著差异（P=0.007）。在调整混杂变量后，线性回归强调了住院时间与较低维生素 D 水平之间存在显著关联，不足组的住院时间更长（P=0.002）。然而，各组之间在恢复正常氧水平（从 SpO2<93%）的时间间隔或死亡率方面没有显著差异（P>0.05）。
血清维生素 D 水平与住院时间之间存在显著关联。然而，维生素 D 状态与死亡率或恢复正常氧水平的时间间隔之间的关系不显著。
