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一生中的酒精使用轨迹:童年预测因素的影响及对晚年健康的后果

Alcohol use trajectories across the life course: Influences of childhood predictors and consequences for late-life health.

作者信息

Szabó Ágnes, Towers Andy, Newcombe David, Sheridan Janie

机构信息

School of Health Sciences, Massey University, New Zealand; School of Health, Victoria University of Wellington, New Zealand.

School of Health Sciences, Massey University, New Zealand.

出版信息

Drug Alcohol Depend. 2021 Jul 1;224:108713. doi: 10.1016/j.drugalcdep.2021.108713. Epub 2021 Apr 26.

Abstract

BACKGROUND

The cumulative, negative health effects of alcohol consumption are exacerbated in older adulthood. We used a 'life course epidemiology' approach to explore how alcohol use trajectories develop across the lifespan, what early life events influence these trajectories and their associations with late-life health.

METHODS

Survey data combined with retrospective life course history interviews were collected from 749 non-lifetime alcohol abstainer adults aged 61-81 years (51 % female). Frequency and quantity items of the AUDIT-C assessed alcohol use across each decade of life. Early life factors were childhood socioeconomic status, parental health behaviours, and age of drinking onset. Health outcomes were alcohol-related conditions.

RESULTS

Latent class growth analysis yielded two life course trajectories for women: consistently infrequent, low quantity drinking (Group 1: 48 %) and increasingly frequent, low quantity drinking (Group 2: 52 %). Men showed three trajectories: consistently infrequent, low quantity drinking (Group 3: 36 %); increasingly frequent, low quantity drinking (Group 4: 51 %); and drinking with increasing frequency and quantity until midlife, after which consumption gradually declined (Group 5: 13 %). Better childhood socioeconomic status was associated with Groups 2 and 4. Later drinking onset was associated with Groups 1 and 3. Parental alcohol misuse, early drinking initiation and childhood socioeconomic adversity were predictive of Group 5. Those in Group 5 were five-to-seven times more likely to have alcohol-related comorbidities.

CONCLUSIONS

Early life experiences influence life course hazardous alcohol use. Interventions across the life course, from childhood, when drinking may be initiated, through to older adulthood, when sensitivity to alcohol increases, are needed.

摘要

背景

饮酒对健康的累积负面影响在老年期会加剧。我们采用“生命历程流行病学”方法,探讨饮酒模式在整个生命周期中如何发展,哪些早期生活事件会影响这些模式以及它们与晚年健康的关联。

方法

收集了749名年龄在61 - 81岁的非终生戒酒成年人(51%为女性)的调查数据,并结合回顾性生命历程访谈。酒精使用障碍识别测试简表(AUDIT-C)中的频率和数量项目评估了每个十年的饮酒情况。早期生活因素包括童年社会经济地位、父母的健康行为以及饮酒开始年龄。健康结局为与酒精相关的疾病。

结果

潜在类别增长分析得出女性的两种生命历程轨迹:持续饮酒频率低、量少(第1组:48%)和饮酒频率逐渐增加、量少(第2组:52%)。男性呈现三种轨迹:持续饮酒频率低、量少(第3组:36%);饮酒频率逐渐增加、量少(第4组:51%);饮酒频率和量增加直至中年,之后饮酒量逐渐下降(第5组:13%)。较好的童年社会经济地位与第2组和第4组相关。较晚开始饮酒与第1组和第3组相关。父母酗酒、过早开始饮酒和童年社会经济逆境可预测第5组。第5组人群患与酒精相关合并症的可能性是其他组的五到七倍。

结论

早期生活经历会影响生命历程中的危险饮酒行为。需要在整个生命历程中进行干预,从可能开始饮酒的童年时期,到对酒精敏感度增加的老年期。

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