Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Department of Radiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
J Neurotrauma. 2021 Oct 1;38(19):2634-2651. doi: 10.1089/neu.2021.0053. Epub 2021 Jun 8.
Despite multiple prior pharmacological trials in traumatic brain injury (TBI), the search for an effective, safe, and practical treatment of these patients remains ongoing. Given the ease of delivery and rapid absorption into the systemic circulation, inhalational gases that have neuroprotective properties will be an invaluable resource in the clinical management of TBI patients. In this review, we perform a systematic review of both pre-clinical and clinical reports describing inhalational gas therapy in the setting of TBI. Hyperbaric oxygen, which has been investigated for many years, and some of the newest developments are reviewed. Also, promising new therapies such as hydrogen gas, hydrogen sulfide gas, and nitric oxide are discussed. Moreover, novel therapies such as xenon and argon gases and delivery methods using microbubbles are explored.
尽管在创伤性脑损伤 (TBI) 方面进行了多次药理学试验，但仍在寻找对这些患者有效、安全且实用的治疗方法。考虑到吸入气体易于输送且可迅速被吸收到体循环中，具有神经保护特性的吸入气体将成为 TBI 患者临床管理中非常宝贵的资源。在本综述中，我们对描述 TBI 环境中吸入性气体治疗的临床前和临床报告进行了系统评价。综述了多年来一直在研究的高压氧以及一些最新的进展。此外，还讨论了一些有前途的新疗法，如氢气、硫化氢气体和一氧化氮。此外，还探索了氙气和氩气等新型疗法以及使用微泡的输送方法。
