Department of Cardiology, The First Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia, China
Department of Cardiology, The First Affiliated Hospital of Baotou Medical College, Baotou, Inner Mongolia, China.
BMJ Open. 2021 May 3;11(5):e046980. doi: 10.1136/bmjopen-2020-046980.
Frailty status has been recognised as an important prognostic factor of adverse clinical outcomes in various clinical settings. Recently, the role of frailty status in adverse clinical outcomes for COVID-19-infected patients has received increasing attention with controversial results. Hence, we will conduct a comprehensive dose-response meta-analysis to quantitatively evaluate the association between frailty status and adverse clinical outcomes in patients with COVID-19.
The researchers will systematically search PubMed, EMBase, Cochrane Library, ISI Knowledge via Web of Science and MedRxiv or BioRxiv databases (from inception until December 2020) to identify all retrospective and prospective cohort studies. All-cause mortality during hospitalisation will be set as the primary outcome. Univariable or multivariable meta-regression and subgroup analyses will be conducted for the comparison between frail versus non-frail categories. Sensitivity analyses will be used to assess the robustness of our results by removing each included study one at a time to obtain and evaluate the remaining overall estimates of all-cause mortality. To conduct a dose-response meta-analysis for the potential linear or restricted cubic spline regression relationship between frailty status and all-cause mortality, studies with three or more categories will be included.
In accordance with the Institutional Review Board/Independent Ethics Committee of the First Affiliated Hospital of Baotou Medical College, ethical approval is not an essential element for the systematic review protocol. This meta-analysis will be disseminated through publication in a peer-reviewed journal.
CRD42020220226.
虚弱状态已被认为是各种临床环境中不良临床结局的重要预后因素。最近，虚弱状态与 COVID-19 感染患者不良临床结局的关系受到越来越多的关注，但结果存在争议。因此，我们将进行全面的剂量反应荟萃分析，定量评估 COVID-19 患者虚弱状态与不良临床结局之间的关系。
研究人员将系统地检索 PubMed、EMBase、Cochrane 图书馆、ISI Web of Science 知识数据库和 MedRxiv 或 BioRxiv 数据库（从成立到 2020 年 12 月），以确定所有回顾性和前瞻性队列研究。住院期间的全因死亡率将作为主要结局。将虚弱与非虚弱类别进行比较的单变量或多变量荟萃回归和亚组分析。通过一次删除每个纳入的研究来进行敏感性分析，以评估我们的结果的稳健性，从而获得和评估全因死亡率的剩余总体估计值。对于虚弱状态与全因死亡率之间潜在的线性或受限立方样条回归关系，将纳入具有三个或更多类别的研究进行剂量反应荟萃分析。
根据包头医学院第一附属医院的机构审查委员会/独立伦理委员会的规定，系统评价方案不需要伦理批准。本荟萃分析将通过在同行评议的期刊上发表来传播。
PROSPERO 注册号：CRD42020220226。
