Radiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, China.
Anestheisiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
BMJ Open. 2021 Dec 13;11(12):e048323. doi: 10.1136/bmjopen-2020-048323.
Previous studies have shown mixed results that delirium may result in a high risk of adverse clinical outcomes in patients with COVID-19. The aim of this meta-analysis is to summarise the evidence of prevalence, classification, risk factors and outcomes impact of delirium in adult patients with COVID-19.
A systematic search will be performed in PubMed, EMBase, ISI Knowledge via Web of Science and preprint databases (MedRxiv and BioRxiv) (from inception until June 2021) to identify all cohort studies concerning delirium in adult patients with COVID-19. The primary outcome will be the prevalence of delirium with different classifications (hyperactive, hypoactive or mixed type). The secondary outcomes will include the association of risk factors and the association with all-cause mortality during hospitalisation. Univariable or multivariable meta-regression and subgroup analyses will be conducted for the study design and patient characteristics. Sensitivity analyses were used to assess the robustness of our results by removing each included study at one time to obtain and evaluate the remaining overall estimates of primary and secondary outcomes.
Ethical approval is not an essential element for the systematic review protocol in accordance with the Institutional Review Board /Independent Ethics Committee of Beijing Hospital. This meta-analysis will be disseminated through a peer-reviewed journal for publication.
CRD42020224871.
先前的研究结果不一，表明谵妄可能使 COVID-19 患者发生不良临床结局的风险增加。本荟萃分析旨在总结成人 COVID-19 患者谵妄的患病率、分类、危险因素和结局影响的证据。
将对 PubMed、EMBase、ISI Web of Science 知识来源中的预印本数据库（MedRxiv 和 BioRxiv）（从建库起至 2021 年 6 月）进行系统检索，以确定所有关于 COVID-19 成人患者谵妄的队列研究。主要结局为不同分类（活跃型、不活跃型或混合型）的谵妄患病率。次要结局将包括危险因素的相关性以及与住院期间全因死亡率的相关性。将进行单变量或多变量荟萃回归和亚组分析，以研究设计和患者特征进行分层。通过每次删除一项纳入研究来进行敏感性分析，以评估我们结果的稳健性，从而获取并评估主要和次要结局的剩余总体估计值。
根据北京医院的机构审查委员会/独立伦理委员会的规定，系统评价方案不需要伦理批准。本荟萃分析将通过同行评审期刊发表传播。
PROSPERO 注册号：CRD42020224871。
