COVID-19 对女性生育力的影响：系统评价和荟萃分析方案。
Impact of COVID-19 on female fertility: a systematic review and meta-analysis protocol.
机构信息
Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Chengdu University of Traditional Chinese Medicine, Chengdu, China.
出版信息
BMJ Open. 2021 Feb 25;11(2):e045524. doi: 10.1136/bmjopen-2020-045524.
INTRODUCTION
The increased social and economic burden caused by the novel COVID-19 outbreak is gradually becoming a worrisome issue for the health sector. The novel coronavirus invades the target cell by binding to ACE2, which is widely expressed in the ovaries, uterus, vagina and placenta. Significantly, the SARS-CoV-2 is said to interrupt female fertility through regulating ACE2. Thus, it is essential to investigate if the novel COVID-19 hampers female fertility, given that there is no systematic and comprehensive evidence on the association of COVID-19 with female fertility.
METHODS AND ANALYSIS
We will systematically search cohort studies, cross-sectional studies, case-control studies and self-controlled case series designs in the following databases: Web of Science, PubMed, EMBASE, Cochrane Library, Ovid, EBSCO, WHO COVID-19 Database, Chinese Biomedical Databases, China National Knowledge Internet, VIP and WanFang Database. Medical Subject Headings and free-text terms for "COVID-19" AND "female" AND "fertility" will be performed. Eligibility criteria are as follows: population (female patients aged 13-49 years); exposure (infection with SARS-CoV-2); comparison (population without SARS-CoV-2 infections or latent SARS-CoV-2 infections); and outcome (female fertility, such as ovarian reserve function, uterine receptivity, oviducts status and menstruation status). Article screening and data extraction will be undertaken independently by two reviewers, and discrepancies will be resolved through discussion. We will use the I statistics to assess the heterogeneity and perform a meta-analysis when sufficiently homogeneous studies are provided. Otherwise, a narrative synthesis will be performed. We will explore the potential sources of heterogeneity using subgroup analyses and meta-regression.
ETHICS AND DISSEMINATION
Formal ethical approval is not required, and findings will be published in a peer-reviewed journal.
PROSPERO REGISTRATION NUMBER
CRD42020189856.
简介
新型冠状病毒病（COVID-19）的爆发给卫生部门带来了日益严重的社会和经济负担。新型冠状病毒通过与广泛表达于卵巢、子宫、阴道和胎盘的 ACE2 结合而入侵靶细胞。值得注意的是，有研究表明，SARS-CoV-2 通过调节 ACE2 来干扰女性生育力。因此，鉴于目前尚无关于 COVID-19 与女性生育力之间关联的系统而全面的证据，有必要研究新型 COVID-19 是否会损害女性生育力。
方法和分析
我们将系统地检索以下数据库中的队列研究、横断面研究、病例对照研究和自身对照病例系列设计：Web of Science、PubMed、EMBASE、Cochrane 图书馆、Ovid、EBSCO、世界卫生组织 COVID-19 数据库、中国生物医学文献数据库、中国国家知识基础设施、维普和万方数据库。将使用“COVID-19”和“female”和“fertility”的医学主题词和自由文本词进行检索。纳入标准为：人群（年龄 13-49 岁的女性患者）；暴露（感染 SARS-CoV-2）；比较（无 SARS-CoV-2 感染或潜伏 SARS-CoV-2 感染的人群）；结局（女性生育力，如卵巢储备功能、子宫容受性、输卵管状态和月经状况）。将由两名评审员独立进行文章筛选和数据提取，如果存在分歧，则通过讨论解决。我们将使用 I ² 统计量评估异质性，并在提供足够同质研究的情况下进行荟萃分析。否则，将进行叙述性综合。我们将通过亚组分析和荟萃回归来探索潜在的异质性来源。
伦理和传播
不需要正式的伦理批准，研究结果将发表在同行评议的期刊上。
PROSPERO 注册号：CRD42020189856。
Zotero 插件