Department of Transfusion Medicine, Institute of Liver and Biliary Sciences, New Delhi, India.
J Clin Apher. 2021 Aug;36(4):621-627. doi: 10.1002/jca.21902. Epub 2021 May 4.
Adverse donor events (ADEs) are usually mild and short-term with no sequelae, but may cause disinclination toward future donations.
To determine the impact of delayed ADEs (D-ADEs) in addition to immediate ADEs (I-ADEs) on the intention of future donations (IFDs) and to analyze the various associated factors.
ADEs were categorized following the ISBT working group on donor vigilance. Telephonic interviews of the donors were conducted 2 weeks after the whole blood (WB) and plateletpheresis donation to inquire about D-ADEs and IFDs.
A total of 3514 WB and 531 plateletpheresis donors were included in the study. WB donors had an overall higher IFD as compared to plateletpheresis donors (89.53% vs 57.06%, P < .001). A higher IFD was observed in male WB donors as compared to female WB donors (89.95% vs 75%, P < .001). Repeat WB donors had a higher IFD as compared with first-time donors (93.66% vs 81.37%, P < .001). A total of 13.7% WB donors and 19.2% plateletpheresis donors reported D-ADEs. WB donors who experienced D-ADEs had a significantly lower IFD (78.38% vs 91.63%, P < .001) as compared with donors without any ADEs; a similar trend was observed in donors who experienced I-ADEs (69.90% vs 91.63%, P < .001). In WB donors, systemic D-ADEs such as fatigue had a more negative impact on IFDs as compared with localized D-ADEs such as bruises (63.93% vs 86.83%, P < .001).
Both D-ADEs and I-ADEs negatively impact donors' intention to donate again. Systemic D-ADEs had a more negative impact on IFDs as compared with localized D-ADEs.
不良反应事件（ADEs）通常是轻微且短期的，没有后遗症，但可能导致人们不愿意再次捐献。
确定迟发性 ADE（D-ADE）对未来捐赠意向（IFD）的影响，并分析各种相关因素。
根据 ISBT 献血者警戒工作组对 ADE 进行分类。在全血（WB）和血小板单采术捐献后两周，通过电话访谈询问供者迟发性 ADE 和 IFD。
本研究共纳入 3514 名 WB 和 531 名血小板单采术供者。与血小板单采术供者相比，WB 供者的 IFD 总体更高（89.53%比 57.06%，P<.001）。与 WB 女性供者相比，WB 男性供者的 IFD 更高（89.95%比 75%，P<.001）。重复 WB 供者的 IFD 高于首次供者（93.66%比 81.37%，P<.001）。共有 13.7%的 WB 供者和 19.2%的血小板单采术供者报告了 D-ADE。与无 ADE 的供者相比，经历 D-ADE 的 WB 供者的 IFD 显著降低（78.38%比 91.63%，P<.001）；经历 I-ADE 的供者也存在类似趋势（69.90%比 91.63%，P<.001）。在 WB 供者中，与局部 D-ADE（如瘀伤）相比，全身性 D-ADE（如疲劳）对 IFD 的负面影响更大（63.93%比 86.83%，P<.001）。
D-ADE 和 I-ADE 均对供者再次捐赠的意愿产生负面影响。与局部 D-ADE 相比，全身性 D-ADE 对 IFD 的影响更大。
