German Red Cross Blood Service Baden-Württemberg - Hessen, Mannheim, Germany.
Vox Sang. 2012 Feb;102(2):134-9. doi: 10.1111/j.1423-0410.2011.01531.x. Epub 2011 Aug 1.
Within the coming decades, a steadily growing demand for blood products will face a shrinking blood donor population in many countries. After increasing the donor age of repeat donors for whole blood donation (WB) from 68 to 70 years in 2009 in our Blood Service, we investigated whether this is sufficient as a safe and effective strategy to sustain future blood supply.
Between 1 March 2009 and 28 February 2011, WB donations from donors aged between 69 and 70 and their proportion of total donations in 2010 were determined. We analysed adverse reaction rates in donors with respect to sex and age and calculated mean annual donation frequencies.
Of all invited donors, 32·5% responded and contributed 0·98% (men) and 0·56% (women) to all WB units collected in 2010. The overall and systemic adverse reaction rate per 1·000 WB donations declined by age [men: 1·10 (95%CI: 0·84-1·35) vs. 0 (0-0·8), P < 0·0001; 0·99 (0·75-1·23) vs. 0 (0-0·8), P < 0·0001 and women: 1·80 (1·46-2·14) vs. 1·12 (0·1-2·66), P < 0·0001; 1·47 (1·17-1·78) vs. 1·12 (-0·43-2·66), P = 0·0004]. Mean donation frequencies were strongly correlated with increasing age (men: r = 0·953, P < 0·0001; women: r = 0·913, P < 0·0001) with peak values for 70-year-old male: 2·53 ± 1·37 vs. 1·79 ± 1·05, P < 0·0001 and female donors: 2·15 ± 1·06 vs. 1·52 ± 0·78, P < 0·0001.
Elderly donors have very low adverse reaction frequencies and are highly committed to donate blood. Thus, we consider donations from repeat donors aged 69-70 safe and suggest it a powerful short- to midterm strategy to, at least partially, overcome the challenges of the demographic change.
在未来几十年，许多国家的献血人群不断减少，而对血液制品的需求却在稳步增长。在我们的血液中心，自 2009 年起，将全血捐献者的重复献血年龄从 68 岁提高到 70 岁后，我们研究了这种做法是否足以作为一种安全有效的策略来维持未来的血液供应。
2009 年 3 月 1 日至 2011 年 2 月 28 日，我们确定了年龄在 69 至 70 岁之间的全血捐献者及其在 2010 年总捐献量中的比例。我们分析了不同性别和年龄的献血者的不良反应率，并计算了平均每年的献血频率。
在所有受邀的献血者中，32.5%的人做出了回应，他们捐献的血液占 2010 年所有全血采集量的 0.98%（男性）和 0.56%（女性）。每 1000 次全血捐献的总不良反应率和全身性不良反应率随着年龄的增长而下降[男性：1.10（95%CI：0.84-1.35）与 0（0-0.8），P<0.0001；0.99（0.75-1.23）与 0（0-0.8），P<0.0001；女性：1.80（1.46-2.14）与 1.12（0.1-2.66），P<0.0001；1.47（1.17-1.78）与 1.12（-0.43-2.66），P=0.0004]。平均献血频率与年龄呈强相关性（男性：r=0.953，P<0.0001；女性：r=0.913，P<0.0001），70 岁男性的献血频率达到峰值：2.53±1.37 与 1.79±1.05，P<0.0001；女性的峰值为：2.15±1.06 与 1.52±0.78，P<0.0001。
老年献血者的不良反应频率非常低，且献血意愿强烈。因此，我们认为 69-70 岁重复献血者的献血是安全的，并建议将其作为一种短期至中期的有效策略，至少可以部分应对人口变化带来的挑战。
