荧光激活细胞分选术有助于分析一例同时存在AML1-ETO和PML-RARA的急性髓系白血病罕见病例。 - Suppr

FACSorting help to analyze a rare case of acute myeloid leukemia with concurrent AML1-ETO and PML-RARA.

作者信息

Chen Man, Fu Minjing, Wang Aixian, Wu Xueying, Zhen Junyi, Gong Meiwei, Wu Ping, Du Qing, Wang Tong, Liu Hongxing, Wang Hui

机构信息

Department of Laboratory Medicine, Hebei Yanda Ludaopei Hospital, Langfang, China.

出版信息

Int J Lab Hematol. 2021 Dec;43(6):e276-e279. doi: 10.1111/ijlh.13558. Epub 2021 May 4.

DOI:10.1111/ijlh.13558

PMID:33943002

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9292886/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/87e4/9292886/71be6fa59975/IJLH-43-e276-g001.jpg

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FACSorting help to analyze a rare case of acute myeloid leukemia with concurrent AML1-ETO and PML-RARA.荧光激活细胞分选术有助于分析一例同时存在AML1-ETO和PML-RARA的急性髓系白血病罕见病例。

Int J Lab Hematol. 2021 Dec;43(6):e276-e279. doi: 10.1111/ijlh.13558. Epub 2021 May 4.

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[Acute myeloid leukemia (aml) subtype M2 with variation of the t (8;21)translocation and AML1/ETO expression].伴有t(8;21)易位及AML1/ETO表达变异的急性髓系白血病（AML）M2亚型

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MEIS2 Is an Oncogenic Partner in AML1-ETO-Positive AML.MEIS2 是 AML1-ETO 阳性 AML 的致癌伙伴。

Cell Rep. 2016 Jul 12;16(2):498-507. doi: 10.1016/j.celrep.2016.05.094. Epub 2016 Jun 23.

AML1-ETO inhibits acute myeloid leukemia immune escape by CD48.AML1-ETO 通过 CD48 抑制急性髓系白血病免疫逃逸。

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Risk-directed therapy based on genetics and MRD improves the outcomes of AML1-ETO-positive AML patients, a multi-center prospective cohort study.一项多中心前瞻性队列研究表明，基于遗传学和微小残留病（MRD）的风险导向治疗可改善AML1-ETO阳性急性髓系白血病（AML）患者的预后。

Blood Cancer J. 2023 Nov 13;13(1):168. doi: 10.1038/s41408-023-00941-4.

ZFP36L2, a novel AML1 target gene, induces AML cells apoptosis and inhibits cell proliferation.锌指蛋白36样蛋白2（ZFP36L2）是一种新的急性髓系白血病1（AML1）靶基因，可诱导急性髓系白血病（AML）细胞凋亡并抑制细胞增殖。

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RUNX1 mutations enhance self-renewal and block granulocytic differentiation in human in vitro models and primary AMLs.RUNX1 突变增强了人类体外模型和原发性 AML 中的自我更新并阻断了粒细胞分化。

Blood Adv. 2019 Feb 12;3(3):320-332. doi: 10.1182/bloodadvances.2018024422.

Co-expression of AML1-ETO and PML-RARa following treatment of de novo acute myeloid leukemia with AML1-ETO.用AML1-ETO治疗初发急性髓系白血病后AML1-ETO与PML-RARa的共表达

Leuk Lymphoma. 2019 May;60(5):1316-1319. doi: 10.1080/10428194.2018.1520991. Epub 2018 Oct 17.

Recurrent chromosomal translocations: Is proximity a rule?复发性染色体易位：接近是一种规律吗？

Indian J Exp Biol. 2017 Jan;55(1):15-20.

ASXL2 regulates hematopoiesis in mice and its deficiency promotes myeloid expansion.ASXL2 在小鼠造血中起调节作用，其缺失会促进髓系细胞扩增。

Haematologica. 2018 Dec;103(12):1980-1990. doi: 10.3324/haematol.2018.189928. Epub 2018 Aug 9.

Clinical and laboratory features of seven patients with acute myeloid leukemia (AML)-M2/M3 and elevated myeloblasts and abnormal promyelocytes.七例急性髓细胞白血病（AML）-M2/M3 伴中幼粒细胞和早幼粒细胞异常升高患者的临床和实验室特征。

Cancer Cell Int. 2014 Dec 31;14(1):111. doi: 10.1186/s12935-014-0111-y. eCollection 2014.

The molecular signature of oncofusion proteins in acute myeloid leukemia.急性髓系白血病中癌融合蛋白的分子特征。

FEBS Lett. 2010 Jun 18;584(12):2662-9. doi: 10.1016/j.febslet.2010.04.002. Epub 2010 Apr 11.

AML1-ETO and C-KIT mutation/overexpression in t(8;21) leukemia: implication in stepwise leukemogenesis and response to Gleevec.t(8;21)白血病中AML1-ETO与C-KIT突变/过表达：对白血病逐步发生及对格列卫反应的影响

Proc Natl Acad Sci U S A. 2005 Jan 25;102(4):1104-9. doi: 10.1073/pnas.0408831102. Epub 2005 Jan 13.

Simultaneous PML/RARalpha and AML1/ETO expression with t(15;17) at onset and relapse with only t(8;21) in an acute promyelocytic leukemia patient.一名急性早幼粒细胞白血病患者初发时同时存在PML/RARα和AML1/ETO表达及t(15;17)，复发时仅存在t(8;21)。

Cancer Genet Cytogenet. 2000 Nov;123(1):41-3. doi: 10.1016/s0165-4608(00)00297-1.

Association of t(15;17) and t(8;21) in the initial phase of an acute promyelocytic leukemia.

Cancer Genet Cytogenet. 1992 Feb;58(2):177-80. doi: 10.1016/0165-4608(92)90108-k.

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FACSorting help to analyze a rare case of acute myeloid leukemia with concurrent AML1-ETO and PML-RARA.

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